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pde1a

" in TargetMol Product Catalog
  • Inhibitors & Agonists
    11
    TargetMol | Inhibitors_Agonists
  • Recombinant Protein
    1
    TargetMol | Recombinant_Protein
Gisadenafil besylate
UK369003-26, UK 369003-26, UK 36900326
T11400334827-98-4
Gisadenafil besylate (UK 369003-26) is a potent and orally active PDE5 inhibitor (IC50=1.23 nM), 100 times more selective for PDE5 than PDE6, for the study of lower urinary tract symptoms associated with benign prostatic hyperplasia.
  • Inquiry Price
8-10 weeks
Size
QTY
Gisadenafil
UK-369003
T15381334826-98-1In house
Gisadenafil (UK-369003), a selective inhibitor of phosphodiesterase 5 (PDE5) with an IC50 of 3.6 nM, prevents the degradation of cGMP.
  • Inquiry Price
8-10 weeks
Size
QTY
pf-04822163
PF-4822163, PF4822163, PF04822163, PF 4822163, PF 04822163
T283671798334-07-2In house
PF-04822163 is a potent inhibitor of PDE1 with IC50 value of 0.0024 μM.
  • Inquiry Price
6-8weeks
Size
QTY
Osoresnontrine
BI-409306
T85151189767-28-9
Osoresnontrine is a potent and selective inhibitor of PDE9A (IC50 of 52 nM),and can be used in the research of memory.
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TargetMol | Inhibitor Sale
ITI-214 free base
ITI214 free base
T116881160521-50-5
ITI-214 free base, a picomolar PDE1 inhibitor (Ki = 58 pM), exhibits excellent selectivity against other PDE family members and a range of enzymes, receptors, transporters, and ion channels.
  • Inquiry Price
1-2 weeks
Size
QTY
ITI-214
ITI214
T116891642303-38-5
ITI-214 is a picomolar PDE1 inhibitor with excellent selectivity against other PDE family members and against a panel of enzymes, receptors, transporters, and ion channels, exhibits potent PDE1 inhibitory activity (Ki = 58 pM).
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PDE1-IN-2
T123901904611-63-7
PDE1-IN-2 is an PDE1 inhibitor(PDE1C, PDE1B and PDE1A with IC50 values of 6, 140 and 164 nM, respectvely).
  • Inquiry Price
8-10 weeks
Size
QTY
TAK-915
T169761476727-50-0
TAK-915 is a potent, selective, and brain-penetrant phosphodiesterase 2A (PDE2A) inhibitor (IC50: 0.61 nM) with >4100-fold selectivity for PDE2A over PDE1A.
  • Inquiry Price
10-14 weeks
Size
QTY
PDE1-IN-8
T203453
PDE1-IN-8 (Compound 3f) acts as an inhibitor of PDE1, with an IC50 of 11 nM. It hinders cAMP and cGMP signaling pathways, impeding the differentiation and proliferation of cells into myofibroblasts, and demonstrates antifibrotic effects in the Bleomycin-induced rat model of pulmonary fibrosis.
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DSR-141562
T394212007975-22-4
DSR-141562 is a new compound that can be taken orally and has a specific ability to inhibit phosphodiesterase 1 (PDE1) in the brain. This compound exhibits a preference for inhibiting human PDE1B, with an IC50 value of 43.9 nM. It also shows moderate inhibition of human PDE1A (IC50 = 97.6 nM) and PDE1C (IC50 = 431.8 nM). DSR-141562 is particularly useful in the study of positive symptoms, negative symptoms, and cognitive impairments associated with schizophrenia.
    7-10 days
    Inquiry
    pde1-in-4
    T63776
    PDE1-IN-4 is a potent and selective inhibitor of PDE1 (phosphodiesterase-1), acting on PDE1C (IC50: 10 nM), PDE1A (IC50: 145 nM) and PDE1B (IC50: 354 nM). PDE1-IN-4 regulates cAMP (3′,5′-cyclic adenosine monophosphate) and cGMP (3′,5′-cyclic guanosine monophosphate) and exhibits antifibrotic effects. PDE1-IN-4 can inhibit TGF-β1-induced differentiation of human lung fibroblasts, and can be used to study idiopathic pulmonary fibrosis (IPF).
    • Inquiry Price
    10-14 weeks
    Size
    QTY