pbp2a

Sanguisorbigenin (Tomentosolic acid) is a natural antimicrobial agent that inhibits methicillin-resistant Staphylococcus aureus (MRSA).

Cefoxitin (Rephoxitin) is a broad-spectrum, orally available second-generation cephalosporins antibiotic. Cefoxitin interferes with the synthesis of bacterial cell walls. Its activity profile includes Gram-negative and Gram-positive bacteria, and is commonly used in abdominal cavity infections, pelvic infections, and certain types of gynecological infections, and is highly effective against anaerobic bacteria.

PBP4-IN-1 (Compound 1) is an inhibitor targeting penicillin-binding protein 4 (PBP4) in Staphylococcus aureus. By inhibiting the function of PBP4, PBP4-IN-1 enhances the antibiotic activity against methicillin-resistant Staphylococcus aureus (MRSA) mediated by PBP2a. This compound is used in studies involving osteomyelitis caused by Staphylococcus aureus and in research aimed at reversing PBP4-mediated resistance to β-lactam antibiotics.

Anti-MRSA agent 31 (Compound 6) is an agent effective against methicillin-resistant Staphylococcus aureus (MRSA), with a minimum inhibitory concentration (MIC) of 97 μg/mL and a minimum bactericidal concentration (MBC) of 781.25 μg/mL. It exhibits potent antibacterial activity and significant inhibitory action on penicillin-binding protein 2a (PBP2a).

Anti-MRSA agent 35 (Compound 6b) is an agent effective against MRSA. It significantly inhibits the formation of MRSA biofilms, suppresses the expression of penicillin-binding protein (PBP2a), and induces mutations in the mecA virulence gene. This compound exhibits potent bactericidal and fungicidal activities, with MIC50 values against Gram-positive bacteria, Gram-negative bacteria, and fungi ranging from 7.8 to 31.25 μg/mL.

Meliantriol is an active compound in Azadirachta indica (Neem). It can bind to PBP2A and PVL toxin with the binding energies of -6.02 kcal/mol and -8.94 kcal/mol, respectively.

Ceftaroline hydrochloride (T-91825 HCl, PPI-0903M HCl) is an N-phosphorylated cephalosporin antibiotic and the active form released upon dephosphorylation of the prodrug TAK-599 (ceftaroline fosamil) after it enters the body. Its mechanism of action involves high affinity for penicillin-binding protein 2a (PBP2a), which is associated with methicillin-resistant Staphylococcus aureus (MRSA) resistance (IC50 = 0.90 μg/mL). Ceftaroline hydrochloride kills various Gram-positive and Gram-negative bacteria by blocking bacterial cell wall synthesis, including resistant strains such as MRSA, methicillin-resistant Staphylococcus epidermidis (MRSE), and Streptococcus pneumoniae.