p53-mdmx

RO-5963 is a dual inhibitor of p53-MDM2 and p53-MDMX (IC50s: ~17 nM and ~24 nM, respectively).

NSC 146109 hydrochloride is an activator of p53 targeting MDMX. NSC 146109 hydrochloride can be used for studies on breast cancer.

SJ-172550 is a small molecule inhibitor of MDMX (EC50: 5 μM).

MEL23 is an MDM2E3 ligase inhibitor that prevents the E3 ligase activity of the MDM2-MDMX complex. It inhibits the ubiquitination of Mdm2 and p53 in cells, reducing the viability of wild-type p53 cells. Additionally, MEL23 stabilizes MDM2 through a mechanism independent of p53 transcription.

WK-298 is an effective MDM2/MDMX-p53 interaction inhibitor.

MMRi64 is a specific inhibitor of Mdm2-MdmX E3 ligase activity.MMRi64 potently induces p53 accumulation and apoptosis in the p53 pathway in leukemia lymphoma cells, disrupts Mdm2-MdmX interactions, and downregulates Mdm2 and MdmX in leukemia cells.MMRi64 MMRi64 can be used in cancer research.

XI-006 (XI-006) suppresses MDMX with IC50 of 2.5 μM, leading to enhanced p53 stabilization activation and DNA damage, and also regulates MDM2, an E3 ligase.

RO2443 is a dual inhibitor of the MDM2-p53 or MDMX-p53 protein-protein interaction, inducung MDM2 and MDMX dimerization and activating the p53 pathway.

Sulanemadlin (ALRN-6924) is a potent peptidomimetic macrocycle that inhibits p53-MDM2 and p53-MDMX protein-protein interactions, serving as a valuable tool for cancer research [1].

MDMX MDM2-IN-2 is a potent dual inhibitor of p53-MDM2 MDMX, with dissociation constants (Kis) of 0.23 μM for MDM2 and 2.45 μM for MDMX. It disrupts the interaction between p53 and MDM2 proteins, reinstating p53 functionality to induce cell cycle arrest and apoptosis. Additionally, this compound impedes cell migration and invasion, exhibiting notable antitumor activity [1].

Phage-derived 12 1 peptide demonstrates antitumor activity by targeting MDM2 and MDMX, thereby disrupting the MDM2-p53 and MDMX-p53 interactions, with IC50 values of 0.15 and 1.25 μM, respectively [1].