p450 1a1

7-Ethoxy-4-Methylcoumarin is considered an inhibitor of enzymes in cells and has been used in studies of enzyme inhibition and has been used to study the effects of various drugs on the human body.

2-Naphthol is a metabolite of naphthalene, catalyzed by cytochrome P450 isoforms (CYP 1A1, CYP 1A2, CYP 2A1, CYP 2E1, and CYP 2F2). 2-Naphthol is cytotoxic.

2-Pentyl-1H-benzo[d]imidazole is a micromolar level inhibitor of Cytochrome P450 1A1 and 2B1 and has antibacterial activity against Fusarium verticillioides.

Rhapontigenin (Protigenin) is a mechanism-based, selective inactivator of cytochrome P450 1A1 (IC50: 400 nM), an aryl hydrocarbon hydroxylase which activates polycyclic aromatic hydrocarbons that act as procarcinogens. Rhapontigenin is a natural analog of resveratrol with antioxidant and anti-cancer activity. At higher concentrations, rhapontigenin inhibits the proliferation of HL-60R and HepG2 cancer cell lines (IC50: 48 μM).

Rhapontigenin 3'-O-glucoside is a derivative of Rhapontigenin, a P450 1A1 inhibitor, which may be used to prevent cancer.

Glucoarabin, a bioactive glucosinolate, upregulates the phase II detoxification enzyme quinone reductase (NQO1) in Hepa1c1c7 cells when hydrolyzed (hGSL 9), without affecting cytochrome P450 (CYP) 1A1 activity [1].