p 38.5

Imigliptin (KBP 3853) is a novel dipeptidyl peptidase-4 inhibitor for the study of type 2 diabetes.

MK-8998 is a T-type calcium channel antagonist that may be utilized in the treatment of schizophrenia. However, it has not demonstrated efficacy in treating hospitalized patients with acute psychosis, according to the PANSS scores measured at week four.

CGP 38560 is a potent renin inhibitor.

M1-20 is a CDK1 inhibitor. It promotes the ubiquitination of CDK1 through the CUL4-DDB1-DCAF1 complex, leading to its degradation via the proteasome pathway. M1-20 inhibits the formation of the CDK1/CCNB1 complex and exhibits significant anticancer activity against spontaneous breast cancer in the FVB/N MMTV-PyVT mouse model.

Canine KP-10 is a potent kisspeptin that induces a significant gonadotropin and estradiol response in female dogs during estrus.

NNC0165-1273 is a peptide YY (PYY3-36) analogue acting as an intestinal hormone. It shows significantly higher affinity for the Y2 receptor compared to the Y1, Y4, and Y5 receptors. NNC0165-1273 effectively induces anorexia and decreases food intake prompted by nocturnal and ghrelin stimulation through increased satiety. It also inhibits the expression of cFos in NPY/AgRP neurons induced by ghrelin. NNC0165-1273 is applicable in anti-obesity therapy research.

cCF10 is a peptide sex pheromone that facilitates the transfer of the conjugative plasmid pCF10 from donor bacteria containing the plasmid to recipient bacteria lacking it. It activates the bacterial Opp system, allowing entry into the bacteria and inhibiting the accumulation of (p)ppGpp. By preserving the metabolic activity state of bacteria, cCF10 reduces the formation of persistent bacteria.

NVP-EVS459 is a radioconjugate that targets folate receptors (FR). Marked with ^177Lu, NVP-EVS459 can be utilized in research related to tumor diagnosis and treatment.

Peptide P2.2, a non-ribosomal antimicrobial peptide, exhibits potent antibacterial activity, with an MIC50 of 4 μM against V. parahaemolyticus and 32 μM against V. alginolyticus. This peptide enhances the synergistic antimicrobial effects when used in conjunction with antibiotics (e.g., Ofloxacin and Linezolid) and shows negligible hemolytic activity. Peptide P2.2 disrupts bacterial membranes and increases their permeability by modulating proteins involved in the type VI and type III secretion systems. It is applicable in bacterial infection research.

PTD-DBM is a competitive peptide that blocks the interaction between CXXC5 and Dvl, thereby inducing the expression of β-catenin, α-SMA, and type I collagen. Additionally, PTD-DBM promotes skin wound healing activity.

Secretin, canine TFA, is an endocrine hormone that stimulates the secretion of pancreatic fluid rich in bicarbonate. Additionally, Secretin, canine TFA, can regulate the primary cell functions and paracellular permeability of gastric monolayer cells through an Src kinase-dependent pathway.

SP94 is a peptide ligand with high specificity for hepatocellular carcinoma cells. It selectively binds to various hepatocellular carcinoma cell lines in vitro. In mouse models of hepatocellular carcinoma, SP94 inhibits tumor growth by promoting tumor cell apoptosis (apoptosis) and reducing tumor angiogenesis. SP94 can serve as a specific probe for imaging hepatocellular carcinoma and is applicable in hepatocellular carcinoma research.

LLVK is a selective inhibitor of IκB phosphorylation. It effectively reduces LPS-induced pro-inflammatory cytokines (IL-1β, IL-6, TNF-α). LLVK shows potential for research in inflammatory bowel disease and rheumatoid arthritis.

Dimethomorph is a fungicide and sterol biosynthesis inhibitor that inhibits fungal cell wall formation, primarily used for the control of downy mildew and late blight. Dimethomorph also inhibits androgen receptor (AR) activity in MDA-kb2 cells, with an IC₂₀ of 0.263 µM.