oxythiamine

Oxythiamine (Hydroxythiamin) is an antivitamin of thiamine and a transketolase (TK) inhibitor. Oxythiamine inhibits cancer cell proliferation and induces cell cycle arrest. Oxythiamine has potential anticancer activity, inhibits non-oxidative synthesis of ribose, and induces apoptosis.

Oxythiamine diphosphate is a competitivethiamine pyrophosphate inhibitor(Ki of 30 nM).

Oxythiamine chloride HCl is a thiamine antimetabolite that has anticancer activities. It is converted by thiamine pyrophosphokinase to oxythiamine pyrophosphate, a transketolase inhibitor. Oxythiamine decreases transketolase activity in breast cancer. It inhibits the nonoxidative synthesis of ribose and decreases RNA and DNA synthesis in pancreatic cancer. In vivo, oxythiamine induces cell cycle arrest at the G1 phase and apoptosis in an adenocarcinoma model. Oxythiamine, in combination with sorafenib, reduces tumor growth in an SMMC mouse xenograft model and has also been used to induce thiamine deficiency in mice.

Oxythiamine (Hydroxythiamine) chloride, a thiamine antagonist and analogue of anti-metabolite, inhibits transketolase (TK) and suppresses the non-oxidative synthesis of ribose, leading to cell apoptosis. It inhibits cancer cell proliferation and induces apoptosis [1] [2] [3].

Oxythiamin diphosphate ammonium [OxyThDP, OxiTDP] is a potent inhibitor of transketolase (TK).

Benfooxythiamine is a transketolase (TKT) inhibitor that suppresses SARS-CoV-2 replication and enhances the activity of the glycolysis inhibitor 2DG. It exhibits antiviral properties.