oxythiamine

Oxythiamine (Hydroxythiamin) is an antivitamin of thiamine and a transketolase (TK) inhibitor. Oxythiamine inhibits cancer cell proliferation and induces cell cycle arrest. Oxythiamine has potential anticancer activity, inhibits non-oxidative synthesis of ribose, and induces apoptosis.

Oxythiamine diphosphate is a competitivethiamine pyrophosphate inhibitor(Ki of 30 nM).

Oxythiamine chloride HCl is an antimetabolite analog that can inhibit the non-oxidative synthesis pathway of ribose. As a thiamine antagonist, Oxythiamine chloride HCl inhibits transketolase. Oxythiamine chloride HCl can inhibit the proliferation of tumor cells and regulate the apoptosis of cancer cells.

Oxythiamin diphosphate ammonium [OxyThDP, OxiTDP] is a potent inhibitor of transketolase (TK).

Oxythiamine (Hydroxythiamine) chloride, a thiamine antagonist and analogue of anti-metabolite, inhibits transketolase (TK) and suppresses the non-oxidative synthesis of ribose, leading to cell apoptosis. It inhibits cancer cell proliferation and induces apoptosis [1] [2] [3].

Benfooxythiamine is a transketolase (TKT) inhibitor that suppresses SARS-CoV-2 replication and enhances the activity of the glycolysis inhibitor 2DG. It exhibits antiviral properties.