oxazolone

Oxazolone is a haptenating agent that can induce models of acute or chronic colitis and atopic dermatitis. It activates Th1/Th2 responses, leading to weight loss and diarrhea, and the resulting inflammation can be alleviated by anti-IL-4 antibodies, anti-TNF-α antibodies, or IL-13R2α-Fc fusion proteins. It is also suitable for studying gene expression related to inflammatory bowel disease in zebrafish.

3-Phenyl-5-isoxazolone ,with CAS No. 1076-59-1, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. 3-Phenyl-5-isoxazolone provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.

2-Benzoxazolinone (2-Hydroxybenzoxazole) is found in cereals and cereal products. 2-Benzoxazolinone is found in rye seedlings.

ARN14974 is a benzoxazolone carboxamide. ARN14974 is a potent inhibitor of acid ceramidase with IC50 of 79 nM[1].

1. Coixol (MBOA) acts as a central muscle relaxant with an anti-convulsant effect. 2. Coixol interacts with the pituitary to stimulate reproduction in voles. 3. Coixol has the ability to interact with FSH to stimulate follicular development and increase ovulation. 4. Coixol can regulate gene expression, production and secretion of mucin, by directly acting on airway epithelial cells.

PF-07245303 is an ITK/TRK inhibitor that reduces the production of inflammatory factors such as IL-4 and IFNγ, and inhibits the phosphorylation of PLCγ1. It suppresses basophil activation induced by nerve growth factor and inhibits TRKA phosphorylation. Additionally, PF-07245303 decreases oxazolone-induced ear swelling in mouse ear tissue. This compound has applications in research on atopic dermatitis.

Tofacitinib Prodrug-1 is an effective and oral active prodrug to mitigate the systemic adverse effects of Tofacitinib. Tofacitinib Prodrug-1 can effectively attenuate the oxazolone-induced colitis in mice model with low toxicity. Tofacitinib Prodrug-1 is a potential drug candidate for the treatment of ulcerative colitis .

1,4,5,6-Tetrahydroxy-7,8-diprenylxanthone is an oxazolone compound isolated from Garcinia xanthochymus exhibiting cytotoxicity against MDA-MB-435S and A549 cells (IC50=1.3/3.86 μg/ml).