nvp 2

NVP-2 is an effective and selective ATP-competitive cyclin-dependent kinase 9 (CDK9) probe. NVP-2 induces cell apoptosis. NVP-2 inhibits CDK9 CycT activity (IC50: 0.514 nM). NVP-2 shows inhibitory effcts on CDK1 CycB, CDK2 CycA and CDK16 CycY kinases (IC5

NVP-231 is a potent, specific and reversible CerK inhibitor(IC50=12±2 nM) that competitively inhibits ceramide binding to CerK.

Vildagliptin (LAF237) is a cyanopyrrolidine-based, orally bioavailable inhibitor of dipeptidyl peptidase 4 (DPP-4), with hypoglycemic activity. Vildagliptin's cyano moiety undergoes hydrolysis and this inactive metabolite is excreted mainly via the urine.

NVP-TAE 226 (TAE226) is a potent FAK inhibitor (IC50: 5.5 nM), exhibiting even greater efficacy against Pyk2 (IC50: 3.5 nM), and is 10- to 100-fold less effective against IGF-1R, InsR, c-Met, and ALK.

Infigratinib (NVP-BGJ398) (BGJ398) is an orally bioavailable pan FGFR inhibitor (IC50: 0.9 1.4 1 nM for FGFR1 2 3), >40-fold selective for FGFR versus FGFR4 and VEGFR2.

ACC-789 (NVP-ACC789 (ZK202650); ZK-202650) is an effective, specific and orally active inhibitor of the VEGF receptor tyrosine kinases.

NVP-ADW742 is an IGF-1R inhibitor with IC50 of 0.17 μM, >16-fold more potent against IGF-1R than InsR; little activity to HER2, PDGFR, VEGFR-2, Bcr-Abl and c-Kit.

AEE788 (NVP-AEE 788) has been used in trials studying the treatment of Cancer, Glioblastoma Multiforme, and Brain and Central Nervous System Tumors.

NVP-AAD777 is a specific VEGFR-2 inhibitor.

NVP CXCR2 20 is an effective selective CXCR2 antagonist (IC50 = 40 nM) with oral bioavailability.

Siremadlin (NVP-HDM 201) is a potent, orally bioavailable and highly specific p53-MDM2 interaction inhibitor.

NVP-ADW742 (ADW) is an IGF-1R inhibitor with IC50 of 0.17 μM, >16-fold more potent against IGF-1R than InsR; little activity to HER2, PDGFR, VEGFR-2, Bcr-Abl and c-Kit.

12-Hydroxynevirapine (12-hydroxy-NVP; 12-OH-NVP), a significant oxidative metabolite of Nevirapine—an antiviral drug for HIV-1 infections known for potential idiosyncratic hepatotoxicity and skin rashes—undergoes bioactivation through sulphotransferases (SULTs) in the liver and skin to form the reactive species 12-Sulphoxy-nevirapine [1] [2].

NVP-DFF332 is a HIF-2 inhibitor that can be used in ccRCC related research

NVP-CGM097 (CGM097) is an effective and specific MDM2 inhibitor (IC50: 1.7 nM for hMDM2).

Corynoxine B (Cory B), a natural alkaloid isolated from Uncaria rhynchophylla (Miq. ), is an autophagy inducer that enhances the activity of Beclin 1 VPS34 complex and increases autophagy by facilitating the interaction between Beclin 1 and HMGB1 2, which may ameliorate Alzheimer's disease. NVP-BAG956 (NVP-BAG956)