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By Target- Apoptosis
- DNA/RNA Synthesis(2)
- Nucleoside Antimetabolite/Analog(2)
- STAT(1)
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Results for "
nsc 118218
" in TargetMol Product Catalog- Inhibitors & Agonists2
Fludarabine
Cited
NSC 118218, Fludarabinum, F-ara-A
T103821679-14-1
Fludarabine (Fludarabinum) is a fluorinated purine analog, an inhibitor of nucleic acid synthesis and an inhibitor of STAT1 activation. Fludarabine has antitumor activity and can be used for the treatment of leukemia and lymphoma.
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CitedFludarabine Phosphate
NSC 312887 Phosphate, fludara Phosphate, F-ara-A (NSC 312887) Phosphate, F-ara-AMP
T650175607-67-9
Fludarabine Phosphate (NSC 312887 Phosphate) is the phosphate salt of a fluorinated nucleotide antimetabolite analog of the antiviral agent vidarabine (ara-A) with antineoplastic activity. Fludarabine phosphate is rapidly dephosphorylated to 2-fluoro-ara-A and then phosphorylated intracellularly by deoxycytidine kinase to the active triphosphate, 2-fluoro-ara-ATP. This metabolite may inhibit DNA polymerase alpha, ribonucleotide reductase, and DNA primase, thereby interrupting DNA synthesis and inhibiting tumor cell growth.
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