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Results for "

nonpeptidic

" in TargetMol Product Catalog
  • Inhibitors & Agonists
    25
    TargetMol | Inhibitors_Agonists
  • PROTAC Products
    1
    TargetMol | PROTAC
  • Natural Products
    1
    TargetMol | Natural_Products
BMS-202
PD1-PDL1 inhibitor 2, PD-1 PD-L1 inhibitor 2
T31461675203-84-5
BMS-202 (PD1-PDL1 inhibitor 2) is an inhibitor of the PD-1 (Programmed death- 1) PD-Ll (Programmed death-ligand 1) protein protein interaction.
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TargetMol | Inhibitor Hot
Embelin
NSC 91874, Emberine, Embelic acid
T6485550-24-3
Embelin (Embelic acid), isolated from the Japanese Ardisia herb, is an inhibitor of the X-linked inhibitor of apoptosis (IC50: 4.1 uM).
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AS057278
3-Methylpyrazole-5-carboxylic acid
T7476402-61-9
AS057278 (3-Methylpyrazole-5-carboxylic acid) is an D-amino acid oxidase (DAAO) inhibitor.
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TargetMol | Inhibitor Sale
SARS-CoV-2 Mpro-IN-9
SARS-CoV-2 Mpro IN 9, SARS-CoV-2 Mpro-IN 9
T794552754370-99-3In house
SARS-CoV-2 Mpro-IN-9 (compound c7), a nonpeptidic, noncovalent inhibitor of SARS-CoV-2 main protease (Mpro), exhibits potent inhibitory action (IC50 = 0.085 μM) and improved physicochemical and drug metabolism and pharmacokinetics (DMPK) properties. It effectively suppresses viral replication in SARS-CoV-2-infected Vero E6 cells (EC50 = 1.10 μM) and demonstrates low cytotoxicity (CC50 > 50 μM) [1].
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6-8 weeks
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ALE-0540
ALE0540
T9292234779-34-1In house
ALE-0540 is a nonpeptidic heterocyclic molecule that inhibits the binding of NGF to p75 and TrkA, as well as signal transduction and biological responses mediated by TrkA receptors.
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gb-110
T113691252806-70-4
GB-110 selectively induces PAR2-mediated intracellular Ca2+ release in HT29 cells with an EC50 of 0.28 μM. GB-110 is a potent, orally active, and nonpeptidic protease activated receptor 2 (PAR2) agonist.
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6-8 weeks
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GB-110 hydrochloride (1252806-70-4 free base)
GB-110 hydrochloride
T11369L
GB-110 hydrochloride selectively induces PAR2-mediated intracellular Ca2+ release in HT29 cells with an EC50 of 0.28 μM. GB-110 hydrochloride is a potent, orally active, and nonpeptidic protease activated receptor 2 (PAR2) agonist.
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3-6 months
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IFN alpha-IFNAR-IN-1
T11630L844882-93-5
IFN alpha-IFNAR-IN-1 is a nonpeptidic, low-molecular-weight inhibitor that disrupts the interaction between IFN-α and IFNAR, inhibiting MVA-induced IFN-α responses by BM-pDCs (IC50: 2-8 μM).
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6-8 weeks
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ML-00253764 hydrochloride
T120721706524-94-8
ML-00253764 hydrochloride is an antagonist of nonpeptidic melanocortin receptor 4 (MC4R) (Ki and IC50 of 0.16 µM and 0.103 µM, respectively).
    7-10 days
    Inquiry
    PROTAC RIPK degrader-2
    T138461801547-16-9
    PROTAC RIPK degrader-2 is a nonpeptidic PROTAC ,and potently targets serine-threonine kinase RIPK2 and has highly selective for RIPK2 degradation.
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    Brilacidin
    PMX 30063
    T147811224095-98-0
    Brilacidin is a nonpeptidic anti-infective in a new class of defensin mimetics used for the research of eye infections.
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    SB-267268
    T16851205678-26-8
    SB-267268 inhibits human and mouse αvβ3 (IC50s: 0.68 and 0.29 nM, respectively). SB-267268 is a selective and nonpeptidic alpha(v)beta3 and alpha(v)beta5 integrins antagonist (Kis: 0.9, 0.5 and 0.7 nM for human αvβ3, monkey αvβ3 and human αvβ5, respective
    • Inquiry Price
    8-10 weeks
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    apogossypolone (apog2)
    T21786886578-07-0
    Apogossypolone (ApoG2) is a semi-synthesized derivative of gossypol which is a nonpeptidic small molecule inhibitor targeting Bcl-2 family proteins with K i values of 35, 25 and 660 nM for Bcl-2, Mcl-1 and Bcl-X L, respectively. Apogossypolone shows antitumor activities, induces cell apoptosis [1] and autophagy [2]. Apogossypolone also has antifungal activity [3].
    • Inquiry Price
    6-8 weeks
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    RID-F
    Ridaifen-F,Ridaifen F
    T260821020853-03-5
    RID-F is an inhibitor of the nonpeptidic proteasome.
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    6-8 weeks
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    A 74273
    A-74273, A74273
    T26439130316-95-9
    A 74273, a nonpeptidic and renin inhibitor, may be used to treat cardiovascular diseases due to renin inhibition.
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    10-14 weeks
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    jnj-10329670
    T27661400797-24-2
    JNJ 10329670 is a highly potent (Ki of approximately 30 nM), nonpeptidic, noncovalent inhibitor of human cathepsin S with immunosuppressive activity.
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    6-8 weeks
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    NS 11
    NS-11,NS11
    T33734150044-75-0
    NS 11 is an RGD-nonpeptidic mimetic.
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    CAY10727
    T363931671088-84-8
    CAY10727 is an inhibitor of protein arginine deiminase 3 (PAD3; kinact/KI= 15,600 M-1min-1).1It is selective for PAD3 over PAD1, -2, and -4 (kinact/KIs = 360, 1,110, and 1,460 M-1min-1, respectively). 1.Jamali, H., Khan, H.A., Stringer, J.R., et al.Identification of multiple structurally distinct, nonpeptidic small molecule inhibitors of protein arginine deiminase 3 using a substrate-based fragment methodJ. Am. Chem. Soc.137(10)3616-3621(2015)
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    6-8 weeks
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    2-Fluoro-4-iodo benzonitrile
    T38372137553-42-5
    2-Fluoro-4-iodo benzonitrile is a building block.1,2It has been used in the synthesis ofL. infantumtrypanothione reductase (Li-TryR) dimerization and oxidoreductase activity inhibitors.12-Fluoro-4-iodo benzonitrile has also been used in the synthesis of transient receptor potential ankyrin 1 (TRPA1) antagonists.2 1.Revuelto, A., Ruiz-Santaquiteria, M., de Lucio, H., et al.Pyrrolopyrimidine vs imidazole-phenyl-thiazole scaffolds in nonpeptidic dimerization inhibitors of Leishmania infantum trypanothione reductaseACS Infect. Dis.5(6)873-891(2019) 2.Vallin, K.S., Sterky, K.J., Nyman, E., et al.N-1-Alkyl-2-oxo-2-aryl amides as novel antagonists of the TRPA1 receptorBioorg. Med. Chem. Lett.22(17)5485-5492(2012)
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    AR-M 1000390 hydrochloride
    ARM390 Hydrochloride, ARM-390 HCl
    T4236209808-47-9
    AR-M 1000390 hydrochloride (ARM-390 HCl) , also known as ARM-390, is a low-internalizing nonpeptidic δ-selective opioid receptor agonist; derivative of SNC 80. Does not trigger acute desensitization of the analgesic response; reduces CFA-induced hyperalgesia. Brain penetrant following systemic administration.
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    R-PSOP
    T612101185189-97-2
    R-PSOP is a potent and selective nonpeptidic NMUR2 antagonist, exhibiting binding affinity to human and rat NMUR2 with Ki values of 52 nM and 32 nM, respectively. This compound demonstrates moderate central nervous system (CNS) penetration and is valuable in the study of eating disorders, obesity, pain, and stress-related disorders [1].
    • Inquiry Price
    6-8 weeks
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    ATC0065 HCl
    T69170510732-84-0
    ATC0065 dihydrochloride is a novel nonpeptidic and potent melanin-concentrating hormone receptor 1 (MCHR1) selective antagonist.
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    6-8 weeks
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    SC 51316
    T70946133690-62-7
    SC 51316 is a nonpeptidic angiotensin II (AII) receptor antagonist.
    • Inquiry Price
    6-8 weeks
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    gb-110 hydrochloride
    T73854
    GB-110 hydrochloride, a potent and orally active nonpeptidic agonist of the protease-activated receptor 2 (PAR2), selectively triggers PAR2-mediated intracellular Ca2+ release in HT29 cells with an EC50 of 0.28 μM [1].
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