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Search Results for " non-hodgkin "

Targets

13

Compounds

Cat No. Product Name Synonyms Targets
T5354 IRAK4-IN-7 CA-4948 IRAK
IRAK4-IN-7 (CA-4948) is a selective and potent IRAK4 kinase inhibitor with in vivo activity in a TLR4-induced cytokine release model.
T8380 Bendamustine SDX105 Apoptosis , Others , DNA Alkylator/Crosslinker
Bendamustine (SDX105) for the treatment of Non-Hodgkin Lymphomas and Chronic Lymphocytic Leukemia
T9924 Obinutuzumab Obinutuzumab/afutuzumab Others
Obinutuzumab (Obinutuzumab/afutuzumab) GA101) is a glycoengineered Type II CD20 monoclonal antibody in development for non-Hodgkin lymphoma.
T35617 Mitoguazone MGBG,Methyl-GAG Apoptosis , HIV Protease
Mitoguazone (Methyl-GAG) is a selective S-adenosyl-methionine decarboxylase inhibitor that penetrates the blood-brain barrier and disrupts polyamine biosynthesis. Mitoguazone is a synthetic polycarbonyl derivative with a...
T76692 Mosunetuzumab BTCT-4465A Others
Mosunetuzumab (BCT-4465A) is a humanized antibody based on immunoglobulin G1 that targets CD20 (B cells) and CD3 (T cells). Mosunetuzumab redirects T cells to engage and eliminate malignant B cells and can be used to stu...
T40901 Aderbasib INCB007839,INCB7839
Aderbasib (INCB007839) is a highly potent and orally active hydroxamate-based inhibitor of ADAM10 and ADAM17, with low nanomolar affinity. This compound demonstrates strong antineoplastic activity and holds potential for...
T78331 Epcoritamab GEN3013
Epcoritamab (GEN3013) is a bispecific IgG1 antibody that redirects T-cells toward CD3×CD20-positive tumor cells, inducing potent T-cell-mediated cytotoxicity against B-cell non-Hodgkin lymphoma (NHL) cell lines [1].
T78686 Apoptosis inducer 11 Apoptosis
Apoptosis Inducer 11 (compound 3u) promotes apoptosis via the mitochondrial pathway and elicits a G2/M block alongside a marked reduction in the S phase within non-Hodgkin lymphoma cell lines [1].
T76768 Pinatuzumab
Pinatuzumab, a CD22 monoclonal antibody, specifically targets the CD22 cell-surface antigen and is utilized in the synthesis of antibody-drug conjugates (ADCs) for researching a range of diseases, including non-Hodgkin l...
T76765 Veltuzumab
Veltuzumab (IMMU-106), a humanized anti-CD20 monoclonal antibody, exhibits a low EC50 value ranging from 0.08 to 0.09 μg/mL in the Daudi cell line. It is used in cancer research, specifically for non-Hodgkin lymphoma (NH...
T82078 Iladatuzumab MCDS0593A
Iladatuzumab (MCDS0593A), a humanized IgG1 monoclonal antibody targeting CD79B, serves as a precursor for the synthesis of antibody-drug conjugates (ADCs), such as Iladatuzumab vedotin (DCDS0780A), with potential applica...
T68485 Apilimod HCl
Apilimod dimesylate is a potent and selective PIKfyve inhibitor. It exhibits no significant activity at other lipid kinases and protein kinases, including PIP4K, PIP5K, mTOR, PI3K and PI4K. Apilimod dimesylate inhibits c...
T73700 Daunorubicin citrate
Daunorubicin (Daunomycin) citrate, a potent anti-tumor anthracycline antibiotic, acts as a topoisomerase II inhibitor. It effectively inhibits DNA and RNA synthesis, diminishes cancer cell viability, and promotes apoptos...
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