nir-1

NIR dye-1 is a near-infrared (NIR) fluorescent dye which has absorption and emission in the NIR region while retaining an optically tunable hydroxyl group.

FD-1080 free acid, an NIR-II region fluorophore (Ex=1064 nm, Em=1080 nm), facilitates in vivo imaging [1].

IR 813 tosylate is a near-infrared (NIR) fluorescent dye with excitation and emission wavelengths of 815 nm and 840 nm, respectively, used for visualizing regional lymph nodes in mice [1].

IR-251 is a mitochondrion-targeting near-infrared (NIR) fluorescent probe that selectively accumulates in tumor cell mitochondria through organic anion transporting polypeptides (OATPs), leading to mitochondrial dysfunction. By impeding peroxisome proliferator-activated receptor gamma (PPARγ), IR-251 promotes reactive oxygen species (ROS) overproduction, consequently inhibiting the β-catenin signaling pathway as well as associated cell cycle and metastasis proteins. This mechanism contributes to the compound's ability to suppress tumor growth and metastasis [1].

GB-6, a short linear peptide that selectively binds to the gastrin releasing peptide receptor (GRPR), shows potential as a high-contrast imaging probe due to its tumor selectivity and specific accumulation. Overexpression of GRPR in pancreatic cancer enables GB-6, when labeled with near-infrared (NIR) fluorescent dyes or the radionuclide technetium-99m (99mTc), to serve as an effective agent for tumor visualization. Demonstrating excellent in vivo stability, GB-6 yields tumor to pancreatic and intestinal fluorescence signal ratios of 5.2 and 6.3, respectively, in SW1990 subcutaneous xenograft models. Its rapid tumor targeting capability and precise tumor boundary delineation signify GB-6's extensive potential for clinical applications [1].

Trisulfo-Cy5-Alkyne, a near-infrared (NIR) fluorescent dye [1], is a click chemistry reagent equipped with an azide group that engages in copper-catalyzed Click Chemistry reactions.

TPEQM-DMA, a NIR-II photosensitizer, selectively accumulates in cancerous mitochondria and demonstrates potent type-I phototherapeutic efficacy that inhibits the growth of cancer cells. This efficacy aids in overcoming the intrinsic limitations of photodynamic therapy (PDT) in treating hypoxic tumors [1].

NIR-βgal-2, a highly sensitive β-galactosidase-activated near-infrared fluorescent probe, facilitates the visualization of β-galactosidase in breast cancer [1].

NIR-FP is a near-infrared (NIR) fluorescent probe that exhibits high sensitivity and selectivity toward the superoxide anion (O2-), a principal precursor of reactive oxygen species (ROS). This probe facilitates dynamic monitoring of ferroptosis-mediated epilepsy models, including the kainic acid-induced chronic epilepsy model, the pentylenetetrazole-induced acute epilepsy model, and the pilocarpine-induced epilepsy model [1].

IR-990, an activatable NIR-II fluorescent probe featuring an acceptor-π-acceptor (A-π-A) structure, enables real-time in vivo detection of hydrogen peroxide (H2O2). It serves as an effective diagnostic tool for drug-induced liver injury (DILI) [1].

HITCI, a commercially available cationic indocarbocyanine dye, is typically utilized as a laser dye within the near-infrared (NIR) [1] spectrum.

H7 is a second near-infrared (NIR-II) fluorophore [1].

BTCy, a near-infrared (NIR) fluorescence probe, exhibits polarity-sensitive and cell plasma membrane-targeting characteristics. It is applicable for in vivo tumor tissue imaging (λ ex = 561 nm, λ em = 600-700 nm) [1].

800CW acid, a near-infrared (NIR) dye, is suitable for protein labeling and in vivo imaging studies [1].

Alexa Fluor 680 NHS ester, a near-infrared (NIR) fluorescent dye, exhibits an absorption maximum at 679 nm and an emission maximum at 720 nm [1].

Bone-1064, a EuK-based PSMA tetramer bone probe, enables high-contrast visualization of bone within surrounding tissue. It specifically binds to hydroxyapatite in bone tissue and is applicable for NIR-II fluorescence imaging in animal models [1].

CH1055 is a synthetic 970-Da NIR-II fluorophore that is rapidly excreted through the kidneys (~90% within 24 hours) and enables targeted molecular imaging of tumors in vivo when conjugated with anti-EGFR Affibody [1].

Cyanine5.5 amine (Cy 5.5 amine), a Cy5.5 analogue, functions as a near-infrared (NIR) fluorescent dye with excitation and emission wavelengths of 648 nm and 710 nm, respectively. This compound is utilized in synthesizing Cy5.5-labeled nanoparticles, facilitating tracking and imaging through confocal microscopy with minimal fluorescence background, as evidenced in studies [1] [2].

Cyanine7 DBCO, a water-soluble NIR fluorescent dye with a cycloalkyne moiety [1], offers specific functionalities for advanced research applications.

Disulfo-ICG carboxylic acid, a derivative of ICG (Indocyanine Green), is a NIR fluorescent dye [1].

DTNP is a BchE-activated near-infrared (NIR) probe with blood-brain permeability that can inhibit BchE enzyme activity and is used in Alzheimer's disease (AD) research [1].

NIR 880 is a fluorescent red dye [1].

IR 813 perchlorate, a near-infrared (NIR) fluorescent dye (Ex=815 nm, Em=840 nm), is utilized for visualizing regional lymph nodes in mice [1].

IR-1061 is a near-infrared fluorescent organic dye utilized for in vivo OTN-NIR imaging [1].