neuroleptic

Fluphenazine decanoate is dopamine D2 receptor blocke,and is a long-acting phenothiazine neuroleptic that used to treat schizophrenia.

Duoperone is a neuroleptic agent. Duoperone shows antiemetic activity in animal models.

Tefludazine, a novel neuroleptic with a benzindone structure, is a compound with good oral activity and antagonistic effects on dopamine and 5-hydroxytryptamine receptors. Tefludazine has shown potent dopamine (DA) antagonistic activity in in vitro and in vivo test models in mice, rats and dogs. Tefludazine is a therapeutic agent used to treat psychiatric disorders.

Tenilapine is a neuroleptic compound that can be used to study atypical antipsychotics.

Haloperidol (Serenace) is a highly potent neuroleptic by relieving nervous through the depression of nerve function. In addition, haloperidol has shown about 50-fold efficacy than chlorpromazine, another antipsychotic drug. Haloperidol has some potencies in the treatment of delusions and hallucinations. Its effects are primarily attained through blocking dopamine receptors in the mesocortex and limbic system.

Dantrolene is a postsynaptic muscle relaxant by inhibiting Ca2+ ions release from sarcoplasmic reticulum stores by antagonizing ryanodine receptors.

Clozapine (HF 1854) is a tricylic dibenzodiazepine, classified as an atypical antipsychotic agent. It binds several types of central nervous system receptors, and displays a unique pharmacological profile. Clozapine is a serotonin antagonist, with strong binding to 5-HT 2A 2C receptor subtype. It also displays strong affinity to several dopaminergic receptors, but shows only weak antagonism at the dopamine D2 receptor, a receptor commonly thought to modulate neuroleptic activity.

Azaperone (Fluoperidol) is a pyridinylpiperazine and butyrophenone neuroleptic drug with sedative and antiemetic effects, which is used mainly as a tranquilizer in veterinary medicine.

Benzetimide hydrochloride (R4929) is an antagonist of muscarinic acetylcholine receptor.treatment neuroleptic-induced parkinsonism.

Promethazine is a neuroleptic medication and first-generation antihistamine of the phenothiazine family.

Ondansetron hydrochloride dihydrate (GR 38032) is a competitive serotonin type 3 receptor antagonist. It is effective in the treatment of nausea and vomiting caused by cytotoxic chemotherapy drugs, including cisplatin, and has reported anxiolytic and neuroleptic properties.

Bromperidol (R-11333) is a butyrophenone derivative and it is a potent and long-acting neuroleptic. Which is used as an antipsychotic in the treatment of schizophrenia.

Dexetimide ((+)-Benzetimide) is a high-affinity antagonist of the muscarinic receptor. It is a persistent anticholinergic agent and can be used to treat neuroleptic-induced parkinsonism.

Levometiomeprazine is a compound that exhibits antiemetic and neuroleptic properties.

Perazine dimlonate, a compound belonging to the phenothiazine class, exhibits neuroleptic properties. It is primarily used to treat psychotic disorders.

Benperidol Hydrochloride is a potent D2/D4 dopamine receptor antagonist, used as antipsychotic and neuroleptic.

A23887 is a potentially neuroleptic tetracyclic spiro amine that has affinity for dopamine D-2 receptors.

Mesoridazine Besylate (Serentil) is a piperidine neuroleptic drug belonging to the class of drugs called phenothiazines, used in the treatment of schizophrenia. It is a metabolite of thioridazine.

Picobenzide, also known as M-14012-4, is a neuroleptic agent,

Prothipendyl is a neuroleptic azaphenothiazine.

SU 23397 is a structurally unique neuroleptic agent.

Zoloperone is a neuroleptic.

Tiapride is an atypical neuroleptic agent without propensity for causing catalepsy and sedation. Tiapride is a selective antagonist of dopamine D2-receptor with IC 50 values of 1440, 45.8, >100, and 11.7 μM for D1; D2; D3; D4, respectively [1].

Tropatepine is an orally active antagonist of anticholinergic muscarinic. Tropatepine is an antiparkinsonian agent that can be used to combat against extrapyramidal syndrome caused by neuroleptic drugs [1][2].