ndm-1 inhibitor-2

NDM-1 inhibitor-2 is an inhibitor of new delhi metallo-β-lactamase-1 (NDM-1).

IMB-XH1 (Mcl1-IN-2) is a myeloid cell factor 1 (Mcl-1) inhibitor.

Metallo-β-lactamase-IN-16 (compound 18), a sulfone-containing metallo-β-lactamase inhibitor, exhibits antimicrobial activity. It effectively inhibits various metallo-β-lactamases, including NDM-1 (New Delhi metallo-β-lactamase-1), IMP-1 (imipenemase-1), VIM-1 (Verona Integron-encoded Metallo-β-lactamase), and VIM-2. The IC50 values for these enzymes are 0.16 nM, 0.23 nM, 0.31 nM, and 1.0 nM respectively.

Captopril (SQ 14225) hydrochloride is an antihypertensive agent that is a thiol-containing, competitive, orally active angiotensin-converting enzyme (ACE) inhibitor with an IC50 of 0.025 μM, widely used in hypertension and congestive heart failure research. It is also a New Delhi metallo-β-lactamase-1 (NDM-1) inhibitor with an IC50 of 7.9 μM [1] [2] [3].

VIM-2-IN-1 (compound 1dj) is a β-lactamase inhibitor with antibacterial activity, demonstrating an IC50 of 48 μM, and inhibits New Delhi Metal (NDM-1) with an IC50 of 231 μM.

MßL-IN-2I is a potent broad-spectrum metallo-β-lactamase (MβL) inhibitor which inhibits the MβLs NDM-1, VIM-2, ImiS, and L1.

EBL-3183, an indole-2-carboxylate, is a potent, reversible, non-covalent, competitive inhibitor of metallo-β-lactamase (MBL), specifically targeting NDM-1 with a pIC50 of 7.7 [1].

YJ182 is an NDM-1 inhibitor with an IC50 of 0.23 μM, and additionally inhibits IMP-1, VIM-2, GIM-1, and MMP-2 with respective IC50 values of 0.25, 0.61, 0.49, and 6.92 μM. It is utilized in bacterial infection research [1].

Metallo-β-lactamase-IN-15 (Compound ±13), a potent inhibitor of MBL, demonstrates IC 50 values of 0.29 μM for NDM-1, 0.088 μM for IMP-1, and 0.063 μM for VIM-2, respectively [1].