n-alkylated

PFM01 is an inhibitor of MRE11 endonuclease. PFM01 can regulate double-strand break repair (DSBR) by nonhomologous end-joining (NHEJ) versus homologous recombination (HR).

[DPro10] Dynorphin A (1-11)acetate,porcine is a highly potent κ-opioid receptor agonist with a Ki value of 0.13 nM. [DPro10] Dynorphin A (1-11), porcine is an n-alkylated derivative with analgesic activity.

Mesocarb HCl is a psychoactive stimulant with an N-alkylated amphetamine structure, known for its selective inhibition of dopamine uptake.

S2157, a potent N-alkylated tranylcypromine (TCP) derivative lysine-specific demethylase 1 (LSD1) inhibitor, enhances H3K9 methylation and concurrently reduces H3K27 acetylation at super-enhancer sites. This compound triggers apoptosis in TCP-resistant T-cell acute lymphoblastic leukemia (T-ALL) cells by inhibiting NOTCH3 and TAL1 gene expression. Moreover, S2157 is capable of crossing the blood-brain barrier, effectively eliminating central nervous system (CNS) leukemia in mice models implanted with T-ALL cells.

S2116 is a powerful inhibitor of lysine-specific demethylase 1 (LSD1), and it is a derivative of N-alkylated tranylcypromine (TCP). S2116 exhibits its inhibitory effects by increasing H3K9 methylation and inducing reciprocal H3K27 deacetylation at super-enhancer regions. In TCP-resistant T-cell acute lymphoblastic leukemia (T-ALL) cells, S2116 triggers apoptosis by repressing the transcription of NOTCH3 and TAL1 genes. Furthermore, S2116 demonstrates significant growth retardation of T-ALL cells when xenotransplanted into mice.

[DPro10] Dynorphin A (1-11), porcine, an N-Alkylated derivative, serves as a potent κ-opioid receptor agonist with a Ki value of 0.13 nM, exhibiting analgesic properties [1] [2].

[DPro10] Dynorphin A (1-11), porcine hydrochloride, is an N-alkylated derivative and potent κ-opioid receptor agonist with a K i value of 0.13 nM, possessing analgesic properties [1] [2].

Nucleoside Derivatives - C-Nucleosides; N-Alkylated nucleosides; Fluoro-modified nucleosides

N1-Cyclopropylmethylpseudouridine is a Nucleoside Derivative - C-nucleoside; N-Alkylated nucleoside.

N1-Methyl-N3-[(2S)-2-(t-butoxycarbonyl)amino-3-(t-butoxycarbonyl)] propylpseudouridine is a nucleoside derivative categorized as a C-nucleoside and an N-alkylated nucleoside.

N1-Propargylpseudouridine is a Nucleoside Derivative - C-nucleoside; N-Alkylated nucleoside.

Nucleoside Derivatives - C-Nucleosides, N-Methylated/alkylated nucleosides

N1-Ethoxymethyl pseudouridine is a Nucleoside Derivative - C-nucleoside;N-Alkylated nucleoside.

N3-Ethyl pseudouridine is a Nucleoside Derivative - C-nucleoside; N-Alkylated nucleoside.

Nucleoside Derivatives - C-Nucleosides; Fluoro-modified nucleosides; N-Alkylated nucleosides

N1-Cyanomethyl pseudouridine is a Nucleoside Derivative - C-nucleoside;N-Alkylated nucleoside.

N1,N3-Bis(cyanomethyl)pseudouridine is a nucleoside derivative categorized as a C-nucleoside and an N-alkylated nucleoside.

Nucleoside Derivatives - C-nucleosides; N-Methylated alkylated nucleosides

Nucleoside Derivatives - C-Nucleosides, N-Methylated/ alkylated nucleosides

Nucleoside Derivatives - Xylo nucleosides, 8-Modified purine nucleosides; N-Methylated alkylated nucleosides

Nucleoside Derivatives - Xylo-nucleosides; 8-Modified purine nucleosides; Amino nucleosides; N-Methylated alkylated nucleosides

Nucleoside Derivatives - Xylo-nucleosides; 8-Modified purine nucleosides; N-Methylated alkylated nucleosides

N1,2'-O-dimethylguanosine is a naturally occurring RNA-modifying nucleoside formed by the simultaneous methylation of the N1 base and the 2'-O position of guanosine. N1,2'-O-dimethylguanosine is primarily found in the variable loop region of tRNA and plays a role in maintaining tRNA structural stability and translation fidelity.

7-Ethyl-7,8-dihydro-8-oxo-9-(beta-D-xylofuranosyl)guanine is a nucleoside derivative (xylo-nucleoside), specifically an N-methylated alkylated nucleoside and an 8-modified purine nucleoside.