mutans

Isobavachromene is an inhibitor of NADH-Ubiquinone oxidoreductase and ornithine decarboxylase. Isobavachromene has antifungal activity.

exo-α-Arabinosidase, Rhodanobacter ginsenosidimutans Gsoil 3054T (EC.3.2.1.55), is a glycoside hydrolase enzyme.

D-Cysteine, the D-isomer of cysteine, is a powerful inhibitor of E. coli growth and is mediated by D-amino acid oxidase to produce H2S, serving as a neuroprotective agent against cerebellar ataxia. Additionally, D-cysteine can inhibit the growth and cariogenicity of a two-species biofilm formed by Streptococcus mutans and Streptococcus hemoglobin.

G43 is a potent and selective glucosyltransferase inhibitor that inhibits GtfB and GtfC with Kd values of 3.7 μM and 46.9 nM, respectively.G43 exhibits in vitro and in vivo anti-Streptococcus mutans activity and can be used for caries studies.

Feudomycin A (13-Deoxydaunorubicin), an anthracycline antibiotic produced by Streptomyces mutans, can be converted to adriamycin with potential antitumor activity by specific microorganisms.

Pterin is a pteridine with antibacterial properties, identified in C. croceus. It inhibits the proliferation and biofilm formation of E. coli, P. aeruginosa, and S. mutans. Pterin holds potential for research in cancer and infections.

Antibacterialagent 263 (compound 5a) is a potent antibacterial agent, exhibiting activity against Streptococcus mutans and Staphylococcus aureus.

Anticaries agent-1 (Compound 21b) is utilized as an anticaries agent. It effectively inhibits biofilm formation with an IC50 of 77 μM and restricts the growth of S. mutans.

β-Defensin-3 is a peptide with antimicrobial properties that protects the skin and mucosal membranes of the respiratory, genitourinary, and gastrointestinal tracts. It inhibits the growth of the periodontopathogenic and cariogenic bacteria F. nucleatum, S. mutans, S. sobrinus, S. salivarius, and L. casei (MICs = 12.5-100 mg/l). It also inhibits the growth of S. aureus, S. pyogenes, P. aeruginosa, E. coli, and C. albicans. β-Defensin-3 stimulates gene expression and production of IL-6, IL-10, CXCL10, CCL2, MIP-3α, and RANTES by keratinocytes when used at a concentration of 30 μg/ml. It also stimulates calcium mobilization, migration, and proliferation of keratinocytes when used at concentrations of 30, 5, and 20 μg/ml, respectively. β-Defensin-3 induces IL-31 production by human peripheral blood-derived mast cells in vitro when used at a concentration of 10 μg/ml and by rat mast cells in vivo following a 500 ng intradermal dose.

Anacardic acid diene is a polyunsaturated form of anacardic acid found in cashew nut shell liquid. It exhibits antibacterial activity against methicillin-resistant S. aureus (MRSA) and S. mutans with MICs of 12.5 and 6.25 μg/ml, respectively. Anacardic acid diene shows schistosomicidal activity against adult S. mansoni worms at 100 μM and also inhibits soybean lipoxygenase-1 in a time-dependent manner.

Octanoic acid-13C is intended for use as an internal standard for the quantification of octanoic acid by GC- or LC-MS. Octanoic acid is a medium-chain saturated fatty acid. It has been found in Teleme cheeses made from goat, ovine, or bovine milk.1 Octanoic acid is active against the bacteria S. mutans, S. gordonii, F. nucleatum, and P. gingivalis (IC80s = <125, <125, 1,403, and 2,294 μM, respectively).2 Levels of octanoic acid are increased in the plasma of patients with medium-chain acyl-CoA dehydrogenase (MCAD) deficiency, an inborn error of fatty acid metabolism characterized by hypoketotic hypoglycemia, medium-chain dicarboxylic aciduria, and intolerance to fasting.3,4 |1. Mallatou, H., Pappa, E., and Massouras, T. Changes in free fatty acids during ripening of Teleme cheese made with ewes', goats', cows' or a mixture of ewes' and goats' milk. Int. Dairy J. 13(1-3), 211-219 (2003).|2. Hyang, C.B., Alimova, Y., Myers, T.M., et al. Short- and medium-chain fatty acids exhibit antimicrobial activity for oral microorganisms. Arch. Oral Biol. 56(7), 650-654 (2011).|3. Onkenhout, W., Venizelos, V., van der Poel, P.F.H., et al. Identification and quantification of intermediates of unsaturated fatty acid metabolism in plasma of patients with fatty acid oxidation disorders. Clin. Chem. 41(10), 1467-1474 (1995).|4. Rinaldo, P., O'Shea, J.J., Coates, P.M., et al. Medium-chain acyl-CoA dehydrogenase deficiency. Diagnosis by stable-isotope dilution measurement of urinary n-hexanoylglycine and 3-phenylpropionylglycine. N. Engl. J. Med. 319(20), 1308-1313 (1988).

Macelignan (Anwuligan) is a lignan isolated from nutmeg with antimicrobial and anticariogenic activity against Streptococcus mutans and other streptococcus species.

Erlose (Fructomaltose) is a sucrose derivative found in honeydew from two aphid species, preventing tooth decay caused by oral bacteria, mainly Streptococcus mutans.

1. Guaijaverin (Quercetin-3-Arabinoside) is a urease inhibitor. 2. Guaijaverin has antioxidant activity. 3. Guaijaverin has antibacterial activity against Strep. mutans.

Antibacterial agent 114 (compound 1) is a potent antibacterial agent with MIC values of 625 μM for P. aeruginosa, B. subtilis, E. coli, E. faecalis, and S. typhimurium; and 1250 μM for S. mutans and S. aureus microorganisms, respectively [1].

Antibacterial agent 113 was an effective antimicrobial agent (antibacterial) against P. aeruginosa, S. mutans, B. subtilis, E. coli, E. faecalis, S. typhimuriumand and S. aureus microorganisms exhibited antibacterial effects with MIC values of 15625 μM.

HA5 has antimicrobial activity and inhibits the biofilm formation of Streptococcus mutans with an IC50 value of 6.42 μM. HA5 inhibits the production of Streptococcus mutans dextran and the level of eDNA, but it does not inhibit the growth of Streptococcus mutans.

Oleanolic aldehyde, an antimicrobial agent, effectively hinders the growth of oral pathogens Streptococcus mutans and Porphyromonas gingivalis, implicated in dental caries and periodontal disease. The compound exhibits minimum inhibitory concentrations (MICs) of 488 µg/mL and 250 µg/mL against these bacteria respectively [1].

Aurein 2.6, an antibiotic antimicrobial peptide, exhibits activity against various Gram-positive bacteria with minimum inhibitory concentrations (MIC) of 25, 25, 30, 25, and 30 μM for M. luteus, S. aureus, S. epidermis, S. mutans, and B. subtilis, respectively [1][2].

Aurein 3.1 is an antibiotic antimicrobial peptide, while Aurein 2.6 is active against Gram-positive bacteria, showing minimum inhibitory concentrations (MIC) of 80 μM for M. luteus and 50 μM for S. aureus, S. epidermis, S. mutans, and B. subtilis [1] [2].

Macelignan (Standard) is a reference standard for research and analysis in studies involving Macelignan. Macelignan (Anwuligan) is a lignan isolated from nutmeg with antimicrobial and anticariogenic activity against Streptococcus mutans and other streptococcus species.

Guaijaverin (Standard) is a reference standard for research and analysis in studies involving Guaijaverin. 1. Guaijaverin (Quercetin-3-Arabinoside) is a urease inhibitor. 2. Guaijaverin has antioxidant activity. 3. Guaijaverin has antibacterial activity against Strep. mutans.

(-)-Asimilobine shows antioxidative, anti-acetylcholinesterase (AChE), anti-α±-glucosidase, anti-leishmanial and anti-fungal activities; it displays weak inhibition against Streptococcus mutans (ATCC 25175), with a minimum inhibition concentration (MIC) o

Gancaonin G shows antibacterial effects on the MRSA strains with MIC values of 16 microg/ml, it also shows more moderate antibacterial activity against Streptococcus mutans.