monomethyl

Hexaethylene glycol monomethyl ether, a PEG-based PROTAC linker, facilitates the synthesis of PROTACs[1].

Nonaethylene glycol monomethyl ether, a PEG-based PROTAC linker, facilitates PROTAC synthesis[1].

Octaethylene glycol monomethyl ether, a PEG-based linker, serves as an essential component in the synthesis of PROTACs[1].

Pentaethylene glycol monomethyl ether (PEG-MME) is a PEG-based PROTAC linker, which is employed for the synthesis of PROTACs[1].

Tetraethylene glycol monomethyl ether, a PEG-based PROTAC linker, is employed for the synthesis of PROTACs[1].

Vat-Cit-PAB-Monomethyl Dolastatin 10 is an ADC linker-conjugated drug designed to deliver potent antitumor activity through Monomethyl Dolastatin 10, a potent tubulin inhibitor, connected via the Vat-Cit-PAB (ADC linker).

Monomethyl fumarate D3 is a deuterium labeled Monomethyl fumarate.

Monomethyl itaconate serves as a copolymerization agent and is an active metabolite of the prodrug SCD-153. Additionally, it has been detected in U. maydis. This compound has applications in the creation of copolymeric hydrogels for producing methotrexate-containing polymer disks and is also utilized in synthesizing thrombin inhibitors.

Monomethyl sebacate is a biochemical.

Koaburaside monomethyl ether is a natural product of Croton, Euphorbiaceae. The catalog number is TN4393 and the CAS number is 41514-64-1. Koaburaside monomethyl ether can be used as a reference standard.

Monomethyl fumarate is a potent agonist of GPR109A .

Hematoporphyrin monomethyl ether is a porphyrin photosensitizer that can be used in studies of port wine stains.

Monomethyl auristatin E (MMAE) (MMAE), an antimitotic agent, inhibits cell division by blocking the polymerization of tubulin and also has inhibition of antibody-drug conjugates (ADCs) activity.

Monomethyl lithospermate (Lithospermic acid monomethyl ester) has potential antiviral activity, alleviating ischemic stroke injury in vivo in middle cerebral artery occlusion mice by activating PI5K/Akt signaling and protecting oxygen-glucose deprivation/reoxygenation-induced SHSY-3Y cells in vitro. Monomethyl lithospermate could improve the viability of SHSY-5Y cells, inhibit mitochondrial membrane potential (MMOP) collapse, and inhibit cell apoptosis. Monomethyl lithospermate also reduced the level of oxidative stress in the brain tissue of middle artery occlusion (MCAO) rats and improved nerve damage in ischemic stroke (IS) rats.

Pinosylvin monomethyl ether is an aromatic compound demonstrating inhibitory activity against A2780, J774, and HEK293 cells.

m-PEG12-OH (Dodecaethylene Glycol Monomethyl Ether) is a PEG-based PROTAC linker. m-PEG12-OH can be used in the synthesis of PROTACs. m-PEG12-OH is also a non-cleavable 12 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

D8-MMAE (D8-Monomethyl auristatin E) is an effective mitotic inhibitor and tubulin inhibitor, deuterated MMAE.

MMAF-OMe (Monomethyl auristatin F methyl ester) is an antitubulin agent which inhibits several tumor cell lines with IC50s of 0.056 nM, 0.166 nM, 0.183 nM, and 0.449 nM for MDAMB435/5T4, MDAMB361DYT2, MDAMB468, and Raji (5T4-) cell lines, respectively. MMAF-Ome is also an ADC cytotoxin.

m-PEG10-alcohol, also known as Decaethylene glycol monomethyl ether, is a non-cleavable 10 unit PEG ADC linker utilized in the synthesis of antibody-drug conjugates (ADCs)[1]. Additionally, m-PEG10-alcohol serves as a PEG-based PROTAC linker, enabling its application in the synthesis of PROTACs[1].

MMAF (MonoMethyl auristatin F), an antimitotic agent, inhibits cell division by blocking the polymerization of tubulin.

MMAD (Demethyldolastatin 10) is a potent tubulin inhibitor. MMAD is a toxin payload in antibody drug conjugates (ADCs).

Methyl potassium malonate is a protein advanced glycosylation inhibitor.

m-PEG-OH (MW 1000) serves as a macromolecular initiator, facilitating the synthesis of amphiphilic block copolymers. These copolymers are utilized to create nanoscale micelles for delivering active drugs. When hydrophobic anti-cancer agent Paclitaxel is encapsulated within these micelles, it demonstrates enhanced activity against cancer cells compared to free Paclitaxel. Additionally, it predominantly accumulates in tumor tissues, with only limited distribution in healthy organs.

m-PEG-OH (MW 10000) serves as a macromolecular initiator in the synthesis of amphiphilic block copolymers, which can be used to create nanoscale micelles for delivering active drugs. These micelles encapsulate the hydrophobic anticancer agent Paclitaxel and exhibit greater efficacy in killing cancer cells compared to free Paclitaxel. Moreover, they preferentially accumulate in tumor tissues while having limited distribution in healthy organs.