melanocortin 3 (mc3)

[D-Trp8]-γ-MSH acetate(321351-81-9 free base) is a selective melanocortin 3 (MC3) receptor agonist (IC50 values are 6.7, 340 and 600 nM for human MC3, MC5 and MC4 receptors respectively) and displays anti-inflammatory efficacy.

AP1189 acetate is a biased agonist at melanocortin 1 and melanocortin 3 receptors.

SHU 9119 is a potent ligand of human melanocortin receptors, exhibiting dual pharmacological properties: it acts as an antagonist at MC3R and MC4R, while functioning as a partial agonist at MC5R. The IC50 values of SHU 9119 against MC3R, MC4R, and MC5R are 0.23, 0.06, and 0.09 nM, respectively.

[D-Trp8]-γ-MSH TFA is a potent, selective agonist for the melanocortin 3 (MC3) receptor, with IC50 values of 6.7 nM for hMC3, 600 nM for hMC4, and 340 nM for hMC5 in CHO cells. It shows potential for providing protection against various inflammatory disorders, including rheumatoid arthritis and colitis [1] [2].

γ-1-Melanocyte Stimulating Hormone (MSH), amide, an 11-amino acid peptide, plays a critical role in regulating sodium (Na+) balance and blood pressure by activating melanocortin receptor 3 (MC3-R).

[D-Trp8]-γ-MSH is a selective melanocortin 3 (MC3) receptor agonist with IC50 values of 6.7, 340, and 600 nM for human MC3, MC5, and MC4 receptors, respectively. [D-Trp8]-γ-MSH also exhibits anti-inflammatory efficacy.