marv

SP187 (MON-DNJ) is a host-targeted iminosugar. It has anti-filovirus infection activity.SP187 is used for therapeutic use against influenza and dengue viruses.

Tamoxifen is an orally active selective estrogen receptor modulator (SERM) that acts as an estrogen antagonist in breast cells and an agonist in bone, liver, and uterine cells. It can be used to induce gene knockout and liver injury models in mice, and also exhibits multiple biological activities, including activation of Hsp90, induction of autophagy and apoptosis, and inhibition of EBOV and MARV viral infections.

Toremifene (GTx 006) is a selective estrogen-receptor modulator (SERM).

Antiviralagent 59 (compound 58) is a selective antiviral agent with drug-like properties, capable of inhibiting a broad spectrum of filoviruses. It demonstrates low off-target activity and inhibitory effects against replicative forms of Ebola virus (EBOV), Sudan virus (SUDV), and Marburg virus (MARV).

Amb21795397 is a blocker of the MARV VP40 PPxY-host Nedd4 interaction.

CP19, a histamine receptor antagonist, serves as an entry inhibitor for Ebolavirus (EBOV) and Marburgvirus (MARV), with inhibitory concentrations (IC50s) of 3.4 μM for EBOV and 29.5 μM for MARV, and selective index (SI) values of 29.4 for EBOV and 3.4 for MARV, indicating its antiviral activity against these viruses.

Eritoran, a Toll-like receptor 4 (TLR4) antagonist, effectively protects mice from lethal infections caused by viruses such as the Ebola virus (EBOV) and Marburg virus (MARV). By decreasing granulocytosis levels, Eritoran may reduce the severity of cytokine storms, thereby inhibiting the pathogenesis of filovirus infections [1].

Tamoxifen (Standard) is the standard substance of Tamoxifen, and it is applicable for quantitative analysis, quality control, and related research in biochemical experiments. Tamoxifen is an orally active selective estrogen receptor modulator (SERM) that acts as an estrogen antagonist in breast cells and an agonist in bone, liver, and uterine cells. It can be used to induce gene knockout and liver injury models in mice, and also exhibits multiple biological activities, including activation of Hsp90, induction of autophagy and apoptosis, and inhibition of EBOV and MARV viral infections.