marv

SP187 (MON-DNJ) is a host-targeted iminosugar. It has anti-filovirus infection activity.SP187 is used for therapeutic use against influenza and dengue viruses.

Tamoxifen (Standard) is a reference standard of tamoxifen, suitable for quantitative analysis, quality control, and related research such as biochemical experiments. Tamoxifen is an orally active selective estrogen receptor modulator (SERM) that acts as an antagonist to estrogen in mammary cells and as an agonist in bone, liver, and uterine cells. Tamoxifen (Standard) can be used to induce gene knockout and liver injury models in mice, and possesses various biological activities, including the activation of Hsp90, inducing autophagy and apoptosis, and inhibiting EBOV (IC50 = 0.1 μM) and MARV (IC50 = 1.8 μM) viral infections.

Tamoxifen is an orally active selective estrogen receptor modulator (SERM) that acts as an estrogen antagonist in breast cells and an agonist in bone, liver, and uterine cells. It can be used to induce gene knockout and liver injury models in mice, and also exhibits multiple biological activities, including activation of Hsp90, induction of autophagy and apoptosis, and inhibition of EBOV and MARV viral infections.

Toremifene (GTx 006) is a selective estrogen-receptor modulator (SERM).

Antiviralagent 59 (compound 58) is a selective antiviral agent with drug-like properties, capable of inhibiting a broad spectrum of filoviruses. It demonstrates low off-target activity and inhibitory effects against replicative forms of Ebola virus (EBOV), Sudan virus (SUDV), and Marburg virus (MARV).

SCR005 is a synthetic carbohydrate receptor (SCR) with broad-spectrum antiviral activity. It inhibits the entry of enveloped viruses from several families, including Coronaviridae (SARS-CoV-1, SARS-CoV-2, MERS-CoV), Filoviridae (EBOV, MARV), and Paramyxoviridae (NiV, HeV), as well as the glycosylated non-enveloped rotavirus. SCR005 binds to viral envelope N-glycans, blocking the virus from attaching to host cells or disrupting both attachment and membrane fusion. It demonstrates a preventive effect in hACE2 mice infected with SARS-CoV-2. SCR005 is applicable for the study and prevention of enveloped viral pandemics.

SCR007 is a synthetic carbohydrate receptor (SCR) known for its broad-spectrum antiviral activity. It inhibits the entry of enveloped viruses across several families, including coronaviruses (SARS-CoV-1, SARS-CoV-2, MERS-CoV), filoviruses (EBOV, MARV), and paramyxoviruses (NiV, HeV), as well as glycosylated non-enveloped rotaviruses. SCR007 targets the N-glycans on virus envelopes, blocking viral attachment to host cells or hindering both attachment and membrane fusion. It exhibits preventive effects in hACE2 mice infected with SARS-CoV-2 and can be employed for research and prevention of pandemics caused by enveloped viruses.

Chlorphenoxamine hydrochloride is an antihistamine and anticholinergic agent that also acts as a GPCR antagonist. It can suppress various deadly viral diseases such as SARS-CoV, MERS-CoV, Ebola virus (EBOV), and malaria. The compound exhibits anti-filovirus activity against both EBOV and Marburg virus (MARV), with IC50 values of 1.1 μM and 6.2 μM, respectively. Chlorphenoxamine hydrochloride is utilized in research related to allergic disorders, urticaria, viral diseases, and Parkinson's disease.

Amb21795397 is a blocker of the MARV VP40 PPxY-host Nedd4 interaction.

CP19, a histamine receptor antagonist, serves as an entry inhibitor for Ebolavirus (EBOV) and Marburgvirus (MARV), with inhibitory concentrations (IC50s) of 3.4 μM for EBOV and 29.5 μM for MARV, and selective index (SI) values of 29.4 for EBOV and 3.4 for MARV, indicating its antiviral activity against these viruses.

Eritoran, a Toll-like receptor 4 (TLR4) antagonist, effectively protects mice from lethal infections caused by viruses such as the Ebola virus (EBOV) and Marburg virus (MARV). By decreasing granulocytosis levels, Eritoran may reduce the severity of cytokine storms, thereby inhibiting the pathogenesis of filovirus infections [1].

Tamoxifen-D3 hydrochloride is a deuterium-labeled derivative of Tamoxifen (Citrate), which is an orally active selective estrogen receptor modulator (SERM). It inhibits estrogen activity in breast cells while activating estrogen receptors in other cells such as those in bone, liver, and uterus. Tamoxifen Citrate acts as a potent Hsp90 activator, enhancing the ATPase activity of the Hsp90 molecular chaperone. Furthermore, it effectively suppresses infectious EBOV Zaire and Marburg (MARV) viruses with IC50 values of 0.1 μM and 1.8 μM, respectively. Tamoxifen Citrate also stimulates autophagy and induces apoptosis, and is capable of triggering gene knockout in CreER (T2) transgenic mice.