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Results for "

machr-in-1

" in TargetMol Product Catalog
  • Inhibitors & Agonists
    8
    TargetMol | Inhibitors_Agonists
  • Dye Reagents
    1
    TargetMol | Dye_Reagents
mAChr-in-1
T5476119391-56-9
mAChR-IN-1 is muscarinic cholinergic receptor(mAChR) antagonist (IC50=17 nM).
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1-2 weeks
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mAChR-IN-1 hydrochloride
T5655119391-73-0
mAChR-IN-1 hydrochloride is a potent antagonist of muscarinic cholinergic receptors (mAChR) with an IC50 of 17 nM.
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TargetMol | Inhibitor Sale
Aceclidine
Quinuclidin-3-yl acetate, NSC-657843, NSC657843, NSC 657843, Glaucostat, 3-quinuclidinyl acetate, 3-Acetoxyquinuclidine, 1-azabicyclo[2.2.2]octan-3-yl acetate
T19870827-61-2
Aceclidine (1-azabicyclo[2.2.2]octan-3-yl acetate) is a modulator of M3 mAChR and can be used in studies about treating glaucoma by reducing intraocular pressure.
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6-8 weeks
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TargetMol | Inhibitor Sale
Atropine methyl bromide
Methylatropine bromide
T143452870-71-5
Atropine methyl bromide (Methylatropine bromide) is a quaternary ammonium salt of atropine, characterized as a muscarinic receptor (mAChR) antagonist. It functions as a mydriatic to dilate the pupil during ophthalmic examination. Compared to atropine, it demonstrates reduced penetration into the central nervous system[1][2]. Its high polarity makes it particularly effective in relieving pyloric spasm in infants.
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Cycrimine
T6057777-39-4
Cycrimine is an orally active antagonist of the muscarinic cholinergic receptor (mAChR) M1 that reduces the level of acetylcholine in the Parkinson's model. Cycrimine exhibits antispasmodic activity that can be used in behavioral and mental disorders research [1] [2] [3] [4].
  • Inquiry Price
6-8 weeks
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N-Demethyl MK-6884
T618782102194-36-3
N-Demethyl MK-6884 (compound 34) is a significant allosteric modulator of the M4 mAChR, relevant in Alzheimer's disease research and studies of other M4 mAChR-related diseases [1].
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8-10 weeks
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vu6019650
T73272
VU6019650 is a potent and selective orthosteric antagonist of M5 mAChR ( IC 50 =36 nM), can be used for opioid use disorder (OUD) relief. VU6019650 can cross blood brain barrier, potentially modulates the mesolimbic dopaminergic reward circuitry. VU6019650 blocks Oxotremorine M iodide induced increases of neuronal firing rates of midbrain dopamine neurons in the ventral tegmental area (VTA) [1] [2] .
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8-10 weeks
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M4 mAChR Modulator-1
T89248
M4 mAChR Modulator-1 (compound 23i) acts as a positive allosteric modulator (PAM) of the M4 mAChR. It demonstrates a stronger synergistic effect in β-arrestin recruitment compared to G protein activation when interacting with ACh. Additionally, while its PAM effects are weaker in G protein-mediated responses, they are more potent in β-arrestin recruitment.
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