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lt 673

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  • Inhibitors & Agonists
    2
    TargetMol | Inhibitors_Agonists
Talazoparib
LT-673, BMN-673
T62531207456-01-6
Talazoparib (LT-673) is a new-type PARP inhibitor (IC50: 0.58 nM), It similarly binds to PARP1 2 (Kis: 1.2 0.85 nM).
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TargetMol | Inhibitor Hot
(rac)-Talazoparib
(rac)-Talazoparib, (rac)-LT-673, (rac)-BMN-673
T2042391207454-56-5
(rac)-Talazoparib ((rac)-BMN-673) (Compound 47) is an orally active inhibitor of PARP1 2, with Ki values of 1.2 nM and 0.87 nM, respectively. It inhibits cellular PARylation at an EC50 of 2.51 nM. This compound leads to the accumulation of DNA damage and suppresses the proliferation of BRCA1 2-mutated MX-1 and Capan-1 cells, with IC50 values of 0.3 nM and 5 nM, respectively. Additionally, (rac)-Talazoparib exhibits antitumor activity in mouse models.
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10-14 weeks
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