lpa-2 antagonist 2

LPA2 antagonist 2 is a selective and potent LPA2 antagonist (IC50: 28.3 nM) with potential anticancer activity, inhibits LPA3, and can be used in the study of cancer.

Fasudil hydrochloride (HA-1077) is a potent inhibitor of ROCK1, PKA, PKC, and MLCK with Ki of 0.33 μM, 1.0 μM, 9.3 μM and 55 μM, respectively.

LPA2 antagonist 1 is a highly efficient LPA2 antagonist.

Fasudil (HA-1077) is a potent inhibitor of ROCK1, PKA, PKC, and MLCK.

LPA5 antagonist 2 is a highly water-soluble, selective antagonist of the lysosomal phosphatidic acid receptor 5 (LPA5) that inhibits downstream calcium mobilization (IC₅₀ = 69 nM) and cAMP signaling (IC₅₀ = 340 nM) by blocking the binding of its natural ligand, LPA. LPA5 antagonist 2 significantly alleviates CFA-induced inflammatory pain and nociceptive hypersensitivity and can be used in research related to inflammatory and neuropathic pain.