liposome

5A2-SC8 is an ionizable cationic lipid that is an ideal vehicle for the delivery of small RNAs, interacts with negatively charged cell membranes, and can be used for gene delivery and drug delivery.

DOPE (DOPE) is a neutral helper lipid for cationic liposomes.It is used in combination with cationic phospholipids to increase efficiency during DNA transfection studies as a non-viral method of gene delivery.

Dehydroergosterol (DHE) is a naturally occurring fluorescent sterol analog that is a compound for real-time detection/elaboration of the sterol environment and intracellular sterol transport in organisms. Dehydroergosterol is a cholesterol mimetic that binds to cholesterol-binding proteins and can be used for real-time imaging of living cells. Dehydroergosterol is a cholesterol mimetic that binds to cholesterol-binding proteins and can be used for real-time imaging of living cells.

Dihexadecyl hydrogen phosphate is a phospholipid analog that acts as an emulsifier and is commonly used in the skin care and pharmaceutical industries.

1,2-Distearoyl-sn-Glycero-3-Phosphatidylglycerol sodium, catalog number T67435 and CAS number 200880-42-8, is a valuable organic compound for life sciences research.

DSPE-PEG 2000 is a non-toxic and biodegradable amphiphilic copolymer that can be used to form micelles to deliver nanoparticles.

DHAPC (1,2-Didocosahexaenoyl-sn-glycero-3-phosphocholine) can be used as a fluorine-18 radiolabeling agent for PET imaging of prostate cancer.

Vaxfectin is a lipid adjuvant used in the development of protein and peptide vaccines.Vaxfectin promotes vaccine immunogenicity.

DSPE-PEG-Azide (MW 2000) has an amphiphilic structure and can form lipid bilayers/micelles in water. It can be used to prepare nanoparticles or liposomes as targeted drug carriers.

4A3-SC8 is a modular dendritic macromolecule with cationic and lipophilic groups that enables small RNAs to prolong survival in an aggressive hepatocellular carcinoma model and can be used to synthesize lipid nanoparticles.

NHLP-002 (BP Lipid 218) is an ionizable liposome that can be used to make nanoparticles, often in the form of nanoparticles to deliver mRNA drugs.

POPG sodium salt is a phospholipid with a negative charge and is a component of biological membranes. It can be used to study the function of biological membranes.

Bupivacaine liposome is a form of Bupivacaine encapsulated in liposomes. Bupivacaine acts as an NMDA receptor inhibitor and blocks sodium channels during action potentials, thereby inhibiting the generation and transmission of nerve impulses caused by painful stimuli. The liposomal encapsulation slows the release rate of Bupivacaine, providing prolonged pain relief.

Mitoxantrone hydrochloride liposome is a liposome-encapsulated form of Mitoxantrone hydrochloride (a topoisomerase II inhibitor). Compared to Mitoxantrone hydrochloride alone, this liposomal formulation enhances antitumor activity and prolongs the circulation time of the drug in the body.

Irinotecan liposome is a liposomal-encapsulated form of Irinotecan hydrochloride (a topoisomerase I inhibitor). Compared to Irinotecan, Irinotecan liposome improves antitumor efficacy, reduces the drug release rate, and minimizes the risk of neutropenia.

Cisplatin liposome is a liposome-encapsulated form of Cisplatin. Cisplatin (CDDP) is an antitumor chemotherapy agent that causes DNA damage in cancer cells by cross-linking with DNA. Cisplatin liposome extends the drug's circulation time and enables a gradual release, allowing the medication to accumulate in tumors for effective cytotoxic action.

Paclitaxel liposome is a formulation where paclitaxel is encapsulated within liposomes. Paclitaxel, a natural antineoplastic drug, stabilizes tubulin polymerization. This liposomal form offers reduced acute toxicity, extended paclitaxel half-life, and enhanced accumulation at tumor sites. Paclitaxel liposome is utilized in studies related to breast cancer and locally advanced esophageal squamous cell carcinoma.

Vincristine sulfate liposome is a liposome-encapsulated form of vincristine sulfate, which is an antineoplastic vinca alkaloid. This formulation enhances the drug's circulation time in the body and facilitates gradual release at the site of tumor vasculature.

Doxorubicin liposome is Doxorubicin hydrochloride encapsulated within liposomes. Doxorubicin, a cytotoxic anthracycline antibiotic, is a potent inhibitor of human DNA topoisomerase I and topoisomerase II. The liposomal encapsulation reduces the cardiac toxicity associated with Doxorubicin and extends its circulation time in the body, allowing for effective targeting of tumor tissue.

Amikacin liposome is a formulation where amikacin disulfate is encapsulated in liposomes. Amikacin, an anthracycline antibiotic with cytotoxic properties, exhibits bactericidal effects. The liposomal encapsulation prolongs the drug's release in the lungs while minimizing systemic exposure, thereby reducing overall toxicity.

Verteporfin liposome is a formulation where Verteporfin is encapsulated within liposomes. Verteporfin is a photosensitizer employed in photodynamic therapy to eradicate ocular abnormal blood vessels associated with conditions like age-related macular degeneration. The liposomal encapsulation extends the drug's circulation time, allowing for gradual release and accumulation in neovascular tissues.

C12-200 is a five-tail/branched ionizable cationic lipid that serves as a benchmark lipid material in RNA delivery, demonstrating exceptional performance in mRNA and siRNA lipid nanoparticle (LNP) formulations.

D-Lin-MC3-DMA is a siRNA delivery vector, an ionizable amino-lipid compound. D-Lin-MC3-DMA offers advantages of high loading efficiency, low toxicity, and efficient endosomal escape.

ALC-0315 is an ionizable cationic lipid that serves as a core component of lipid nanoparticle (LNP) delivery systems for mRNA vaccines, responsible for efficiently encapsulating, protecting, and delivering nucleic acids into cells. Lipid nanoparticles have already been used in research on mRNA (COVID-19) vaccines.