kat6a

WM-1119 is a highly potent, selective KAT6A/B inhibitor

CTX-0124143 is a histone acetyltransferase inhibitor with an IC50 value of 1.0 μM for KAT6A.CTX-0124143 can be used to study cellular senescence.

KAT6A-IN-2 (compound 7) is an inhibitor of KAT6A.

KAT6A-IN-1 (compound 5) is an inhibitor of KAT6A.

KAT6-IN-3 (compound 10) competitively targets and binds to KAT6A and KAT6B.

BAY-184 is a selective oral inhibitor of KAT6A and KAT6B with IC50 values of 71 nM and 83 nM, respectively. This compound suppresses estrogen receptor α (ERα) transcriptional activity and impedes cell proliferation across various breast cancer subtypes as well as tumor growth.

MOZ-IN-3 (Compound 6j), a potent KAT6A (MOZ) acetyltransferase inhibitor with an IC50 of 30 nM, exhibits antitumor activity against multiple myeloid leukemia cell lines, including HL-60, U937, SKNO-1, and K562. This compound also demonstrates favorable metabolic stability and pharmacokinetics [1].

MW-2474 is an inhibitor of the lysine acetyltransferase KAT6A.

PF-9363 (CTX-3648) is a potent and high selective KAT6A/KAT6B inhibitor. PF-9363 can be used for the research of cancer.