isosorbide

Isosorbide (Devicoran) is a heterocyclic compound that is derived from glucose, used as a diuretic.

Isosorbide-2-nitrate, a nitric oxide (NO) donor and active metabolite of isosorbide dinitrate, inhibits contraction in rabbit aortic strips induced by potassium chloride or angiotensin II and reduces vasopressin-induced coronary spasm in isolated rabbit hearts at concentrations of 100 and 1,000 µM.

Isosorbide Mononitrate (Corangin) is a Nitrate Vasodilator, dilating the blood vessels so as to reduce the blood pressure.

Isosorbide dinitrate (Isordil) is a vasodilator used in the treatment of angina pectoris.

1,4:3,6-Dianhydro-D-mannitol (1,4:3,6-Dianhydromannitol) is a commonly used intermediate compound and a derivative of Isosorbide .Some derivatives of 1,4:3,6-Dianhydro-D-mannitol exhibit potent inhibitory activity against KLK5 and KLK7.This compound can be used in the study of HCV infection and KLK5/KLK7-related diseases.