imr-32

Paeoniflorin (Peoniflorin) is a herbal constituent extracted from the root of Paeonia albiflora Pall.

MCHR1 antagonist 2 is an inhibitor of melanin-concentrating hormone receptor 1 (MCH1-R, IC50 = 65 nM) and also inhibits hERG.

Ferrostatin-1 (Fer-1) is a potent and selective inhibitor of iron death. Ferrostatin-1 potently inhibits Erastin-induced iron death in HT-1080 cells with an EC50 of 60 nM. Ferrostatin-1 also exhibits antioxidant and antifungal activities.

Ellipticine (Elliptisine) is a potent antineoplastic agent exhibiting multiple mechanisms of action, IC50 of 0.67±0.06, 1.25±0.13, 1.25±0.13, 0.67±0.06, 0.27±0.02, 0.49±0.04, 0.44±0.03, and 1.48±0.62 μM for Leukemia HL-60, Breast adenocarcinoma MCF-7, Breast adenocarcinoma MCF-7, Leukemia HL-60, Neuroblastoma IMR-32, Neuroblastoma UKF-NB-4, Neuroblastoma UKF-NB-3, and Glioblastoma U87 mg cell, respectively.

VK3-OCH3 (2-[(2-Methoxy)ethylthio]-3-methyl-1,4-na) is a selective antitumor agent via heme oxygenase (HO-1) related mechanisms; Vitamine K3 analogue.

UAMC-3203 is a potent and selective ferroptosis inhibitor with an IC50 value of 12 nM.

nAChR agonist 1 (DUN71755) is a brain-permeable and orally efficacious positive allosteric α7 nicotinic acetylcholine receptor (α7 nAChR)modulator.

ATRA-hydroxyimino, also known as CRABP-II ligand 1, is a chemical compound derived from Retinoic acid (ATRA). This compound binds to the cIAP1 ligand, specifically Bestatin, through a linker, resulting in the formation of a complex called SNIPER. The purpose of this complex is to degrade CRABP-II within IMR-32 cells[1].

CZL-S092 is a PLK4 inhibitor with exceptional selectivity for other PLK4 family members (PLK1, PLK2, and PLK3), exhibiting an IC50 of 0.9 nM. It demonstrates antineuroblastoma activity in vitro (IMR-32, IC50 = 1.143 μM) and shows good oral bioavailability in vivo (SD rats, F = 22.1%). CZL-S092 is applicable in research on various cancers, including neuroblastoma.

Antiviralagent 64 (Compound 12) is a diarylheptane compound isolated from *Alpinia officinarum*. In human neuroblastoma IMR-32 cells, it exhibits cytotoxicity with an IC50 of 0.23 μM. Antiviralagent 64 also demonstrates antiviral activity, effectively inhibiting RSV, poliovirus, measles virus, HSV-1, and influenza virus H1N1, with EC50 values of 13.3, 3.7, 6.3, 5.7, and <10 μg/mL, respectively.

β-Amyloid (17-40) (Aβ(17-40)), a fragment of the Amyloid-β peptide, exhibits neurotoxic activities in SH-SY5Y and IMR-32 cells. This compound is utilized in the investigation of neurological diseases [1].