iks

IKs124 is a KCNE2/KCNQ1 potassium channel blocker with an IC50 = 8 nM, as well as an IC50 of 370 nM and 440 nM for KCNE1 and KCNE3, respectively, and can be used to study peptic ulcers.

JNJ 303 is a potent blocker of IKs (IC50 : 64 nM).

HMR 1556 is a chromanol derivative and is an IKs blocker (IC50s of 10.5 nM and 34 nM in canine and guinea pig left ventricular myocytes, respectively).

Anti-CD19 Antibody (IKS03 Naked Antibody) is an antibody targeting CD19 and can be used to generate the ADC IKS03. Anti-CD19 Antibody (IKS03 Naked Antibody) can be used for oncology research.

IKS02 is a phosphatidylcholine (PC) phospholipid that functions as a photoaffinity labeling (PAL) probe.

Wikstrol B is a natural product that can be used as a reference standard. The CAS number of Wikstrol B is 160963-92-8.

(+)-Wikstromol is a useful organic compound for research related to life sciences and the catalog number is T130443.

Wikstrol A, a potent antifungal, antimitotic, and anti-HIV-1 agent, demonstrates significant effects across various biological targets. It induces morphological deformation in P. oryzae mycelia, with a minimum morphological deformation concentration (MMDC) of 70.1 µM and inhibits microtubule polymerization, evidenced by an IC50 value of 131 µM. Additionally, Wikstrol A exhibits anti-HIV-1 activity with an IC50 value of 67.8 µM.

SIKs-IN-1 (compound 8h), a pyrimidine-5-carboxamide derivative, functions as an inhibitor of Salt-inducible kinases (SIKs), which play a role in M1/M2 macrophage polarization linked to inflammation. By inhibiting SIK activity, this compound increases anti-inflammatory cytokine IL-10 and decreases pro-inflammatory cytokine IL-12, demonstrating significant anti-inflammatory efficacy in a DSS-induced colitis model [1].

Wikstroelide E is a natural diterpene.

Ikshusterol 3-O-glucoside has a potent snake-venom neutralizing capacity and it might be a potential molecule for the therapeutic treatment for snakebites.

Ikshusterol is a natural product for research related to life sciences. The catalog number is TN4248 and the CAS number is 34427-61-7.

NIK SMI1 is an effective and selective NF-κB inducing kinase (NIK) inhibitor. It also inhibits NIK-catalyzed hydrolysis of ATP to ADP (IC50: 0.23±0.17 nM).

(+)-Nortrachelogenin is a lignan isolated from Wikstroemia indica C.A. Meyer (Thymelaeaceae). (+)-Nortrachelogenin possesses antileukemic activity.

Nortrachelogenin ((-)-Wikstromol), which can be extracted from Partrinia scabiosaefolia, has antifungal activity and induces membrane disruption and cysteinyl asparagin-dependent apoptosis.

(S)-NIK SMI1 is the isomer of NIK SMI1 and can be used as a control compound in experiments. NIK SMI1 serves as a potent and selective inhibitor of NF-κB-inducing kinase (NIK), effectively blocking the NIK-catalyzed hydrolysis of ATP to ADP, with an IC50 of 0.23±0.17 nM.

Chromanol 293B is an inhibitor of the slow component (IK) of delayed rectifier potassium currents in cardiac cells (IC50 = 1–10 μM) and a weak inhibitor of KATP channels. It also blocks CFTR chloride currents (IC50 = 19 μM) and can be used in arrhythmia research.

HMR-1566 is a potent and selective Iks channel blocker.

Azimilide Dihydrochloride (NE-10064 Dihydrochloride), a novel class III antiarrhythmic agent, blocks both the slowly activating (IKs) and rapidly activating (IKr) components of the delayed rectifier potassium current