hypericum

Hypericin (Cyclosan) is a natural anthraquinone compound, an extract of Hypericum perforatum, which inhibits PKC, MAO, dopamine-beta-hydroxylase, reverse transcriptase, telomerase, and CYP, etc. Hypericin exhibits antimicrobial, antiviral, antitumor, and antidepressant activities.

Stigmastanol is a phytosterol.

Hyperoside (Hyperin) is a naturally occuring flavonoid compound which shows multiple bioactivities, including myocardial protection, anti-redox, and anti-inflammatory activities.

2"-O-Galloylhyperin (FT-0689359) found in Pyrola. It increases ruminal fiber fermentability by formed wall-bound lignin in primary maize cell walls.

1-Eicosanol (Standard) is the standard substance of 1-Eicosanol, and it is applicable for quantitative analysis, quality control, and related research in biochemical experiments. 1-Eicosanol is a natural product isolated from Hypericum carinatum. 1-Eicosanol has antioxidant activity.

Stigmastanol (Standard) is a reference standard for research and analysis in studies involving Stigmastanol. Stigmastanol is a phytosterol isolated from Hypericum riparium, which is a Cameroonian medicinal plant.

Hypericin (Standard) is a reference standard for research and analysis in studies involving Hypericin. Hypericin (Cyclosan) is a natural anthraquinone compound, an extract of Hypericum perforatum, which inhibits PKC, MAO, dopamine-beta-hydroxylase, reverse transcriptase, telomerase, and CYP, etc. Hypericin exhibits antimicrobial, antiviral, antitumor, and antidepressant activities.

Vanillic acid glucoside (Standard) is a reference standard for research and analysis in studies involving Vanillic acid glucoside. Vanillic acid glucoside (Vanillic acid 4-β-D-glucoside) is a dimeric oxaloside isolated from Hypericum persica.

Hypercalin B is an antibacterial agent isolated from the hexane and chloroform extracts of Hypericum acmosepalum. It demonstrates activity against multidrug-resistant strains of Staphylococcus aureus, with a minimum inhibitory concentration (MIC) ranging from 0.5 to 128 mg/L.

Vincetoxicoside B, isolated from Polygonum paleaceum Wall. Vincetoxicoside B , quercetin, kaempferol , and (-)-epicatechin show synergistic antifungal activities with the FICI values <0.5.

Anti-inflammatory agent 75 (Compound 14) is an α-pyrone derivative isolated from the traditional medicinal plant Hypericum henryi. This compound exhibits anti-inflammatory properties by inhibiting the phosphorylation and degradation of the NF-κB inhibitor, thereby preventing the activation of NF-κB.

α-Glucosidase-IN-64 (compound 10) is a potent inhibitor of α-glucosidase with an IC50 value of 8.62 µM. This compound is a polycyclic polyprenylated acylphloroglucinol, which can be isolated from Hypericum beanii.

3,4-O-Isopropylidene-shikimic acid (3,4-O-Isopropylidene shikimic acid) exhibits significant anti-inflammatory, anti-thrombosis, antioxidant, and analgesic effects, and provides protective benefits against trinitrobenzenesulfonic acid-induced experimental colitis in rats, likely because of its antioxidant properties.

3,8'-Biapigenin is a polyketide synthase-derived biflavonoid identified in Hypericum species and has been reported to exhibit diverse biological activities. 3,8'-Biapigenin inhibits protein tyrosine phosphatase 1B (PTP1B) with an IC50 value of 4.5 µM and stimulates glucose uptake in 3T3-L1 adipocyte cells at concentrations of 5 and 10 µM. 3,8'-Biapigenin also inhibits the cytochrome P450 isoforms CYP3A4, CYP2C9, and CYP1A2, with Ki values of 0.038, 0.32, and 0.95 µM, respectively. In isolated rat embryonic hippocampal neurons, 3,8'-Biapigenin reverses cell death induced by kainate and NMDA when applied at a concentration of 10 µM. Furthermore, 3,8'-Biapigenin administered at 8 mg/kg decreases carrageenan-induced paw edema and protects against gastric lesions induced by indomethacin in rats. These findings support the application of 3,8'-Biapigenin as a research tool for investigations involving metabolic regulation, enzyme modulation, neurobiology, inflammatory processes, and xenobiotic metabolism.

Hyperforin, a natural product from Hypericum, is commonly used as an antidepressant and also has neurological, inflammatory, antimicrobial, antitumor and antiangiogenic effects. Hyperforin acts as a monoamine reuptake inhibitor (MRI) in vitro, including serotonin, norepinephrine, dopamine, GABA, and glutamate, with an IC 50 of ≈0.1 μg/mL. Hyperforin is also capable of inducing the cytochrome P450 enzymes, CYP3A4 and CYP2C9, through binding to and activation of the pregnane X receptor. Hyperforin is capable of activating TRPC6 channels by binding to a specific motif.

Mauritianin, a kaempferol glycoside isolated from the flowers and leaves of Acalypha indica, is a topoisomerase I inhibitor with cytoprotective activity.

Protohypericin, a naphthodianthrone derivative found in the plant Hypericum perforatum, exhibits photocytotoxicity and is utilized in tumor necrosis targeted radiotherapy through its radioiodinated form.

Protopseudohypericin is a natural product

Pseudohypericin is a major naphthodianthrone photosensitive pigment found in plants of the genus Hypericum. Pseudohypericin exerts antiretroviral activity by specifically inhibiting protein kinase C (PKC) or interfering with the assembly and maturation of viral particles. Additionally, upon ultrasonic activation, it induces the generation of reactive oxygen species (ROS), thereby triggering cell apoptosis through the mitochondrial-caspase pathway.

Quercetin 3-O-(6''-galloyl)-beta-D-galactopyranoside effectively induces apoptosis through the p53, MAPKs, and mitochondrial apoptotic pathways.

Quercetin 3-O-(6''-O-galloyl)-β-D-glucoside (Quercetin 3-O-(6''-galloyl)-beta-D-glucopyranoside) is a natural product with potent inhibitory activity against the growth of Microcystis aeruginosa.

Taxifolin 7-O-rhamnoside (Taxifolin 7-O-α-L-rhamnoside) is a natural product derived from Hypericum japonicum.

BLV is a natural product for research related to life sciences. The catalog number is TN2484 and the CAS number is 146905-24-0.

2,2-Dimethyl-6-phenylpyrano[3,4-b]pyran-8-one is a natural product derived from the metabolites of Hypericum revolutum ssp.