hache — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T79299	hAChE-IN-3		Monoamine Oxidase
	hAChE-IN-3 (compound 5c) serves as a potent inhibitor for AChE, BuChE, MAO-B, and BACE-1, with respective IC50 values of 0.44, 0.08, 5.15, and 0.38 μM, demonstrating its ability to cross the blood-brain barrier. This com...		Monoamine Oxidase
T78692	hAChE-IN-2
	hAChE-IN-2, a potent inhibitor of human acetylcholinesterase (hAChE), exhibits an inhibitory concentration 50 (IC50) of 0.71 μM and additionally impedes tau-oligomerization with an effective concentration 50 (EC50) of 2....
T82242	hAChE-IN-6
	hAChE-IN-6 (compound 51) is a brain-penetrant acetylcholinesterase (AChE) inhibitor exhibiting an IC50 of 0.16 μM. It also demonstrates inhibitory effects on human butyrylcholinesterase (hBuChE) and glycogen synthase kin...
T79300	hAChE-IN-4
	Compd 5d (hAChE-IN-4) is a potent hAChE inhibitor that readily crosses the blood-brain barrier, exhibiting an IC50 of 0.25 μM, and is utilized in the study of Alzheimer's disease [1].
T78689	hAChE-IN-1
	hAChE-IN-1 (Compound 24) is a potent inhibitor of human acetylcholinesterase (hAChE), exhibiting an inhibition concentration half-maximum (IC50) of 1.09 μM. Additionally, it inhibits tau-oligomerization with an effective...
T82243	hAChE-IN-5		GSK-3
	hAChE-IN-5 (compound 49) is a dual inhibitor of human acetylcholinesterase (hAChE) and human butyrylcholinesterase (hBuChE), exhibiting inhibitory potency with IC50 values of 0.17 μM for both enzymes. Additionally, it de...		GSK-3
T61388	hAChE/Aβ1-42-IN-1
	Compound 16 (hAChE/Aβ1-42-IN-1) is a potent inhibitor targeting both hAChE and Aβ1-42 aggregation, demonstrating considerable safety in hepG2 cell lines and excellent brain-blood barrier (BBB) penetration with a broad sa...
T7041	Donepezil	E2020,Donepezilo,Aricept	AChE
	Donepezil (Aricept) is a piperidine-based, potent, specific, and reversible inhibitor of acetylcholinesterase (AChE). It can be used for the treatment of mild to moderate dementia of the Alzheimer's type.		AChE
T6478	Donepezil Hydrochloride	Aricept,BNAG,E2020,Donepezil HCl	AChR , AChE
	Donepezil HCl(Aricept) is a selective and effective AChE inhibitor for bAChE and hAChE (IC50: 8.12/11.6 nM).		AChR , AChE
T11351	Galanthamine N-Oxide		AChE
	Galanthamine N-Oxide, an alkaloid extracted from Zephyranthes concolor bulbs, effectively inhibits acetylcholinesterase (AChE) from electric eel with an EC50 of 26.2 μM. It acts as a significant inhibitor of substrate ac...		AChE
T60891	AChE/BChE/MAO-B-IN-1		MAO , AChE
	AChE/BChE/MAO-B-IN-1 is a reversible, non-time-dependent inhibitor of AChE, BChE and MAO-B that crosses the blood-brain barrier and exhibits inhibitory effects on hAChE, hBChE and hMAO-B with IC50s of 7.31, 0.56 and 26.1...		MAO , AChE
T72417	AChE/Nrf2 modulator 1
	AChE/Nrf2 modulator 1, an orally active compound, serves as a modulator of acetylcholinesterase (AChE) and nuclear factor erythroid 2-related factor 2 (Nrf2). It exhibits Nrf2 inductive activity alongside inhibitory effe...
T62728	AChE-IN-24
	AChE-IN-24 is a potent inhibitor of AChE that crosses the blood-brain barrier. hAChE is strongly inhibited by AChE-IN-24 (IC50: 0.053 μM). aChE-IN-24 can be used to study Alzheimer's disease (AD).
T60720	AChE/BChE-IN-4
	AChE/BChE-IN-4 (BMC-3) is an AChE and BChE dual inhibitor that can cross the BBB. The IC 50 values of AChE/BChE-IN-4 for human AChE (hAChE) and human BChE (hBChE) are 792 nM and 2.2 nM, respectively[1].
T64143	AChE/GSK-3β-IN-1
	AChE/GSK-3β-IN-1 is a potent dual AChE/GSK-3β inhibitor that crosses the blood-brain barrier and acts on hAChE (IC50: 1.2 nM), hBChE (IC50: 149.8 nM) and hGSK-3β (IC50: 22.4 nM). AChE/GSK-3β-IN-1 is able to occupy the AT...
T63091	BChE-IN-5
	BChE-IN-5 is a potent and selective inhibitor of BChE (IC50: 2.8 nM) and has a higher inhibitory effect on hBChE than hAChE. BChE-IN-5 has potential for use in Alzheimer's disease research.
T73575	SD-6
	SD-6, an orally active inhibitor targeting both hAChE and hBChE, demonstrates IC50 values of 0.907 µM and 1.579 µM, respectively. With its excellent blood-brain barrier (BBB) permeability and lack of neurotoxicity, SD-6 ...
T61638	Dihydro Donepezil
	Dihydro Donepezil, also known as Dihydro E2020, is a metabolite derived from Donepezil. Donepezil is a highly specific and potent inhibitor of acetylcholinesterase (AChE) with IC50 values of 8.12 nM and 11.6 nM for butyr...
T60721	AChE/BChE-IN-5
	AChE/BChE-IN-5 (BMC-16) is an AChE and BChE dual inhibitor that can cross the BBB. The IC 50 values of AChE/BChE-IN-5 for human AChE (hAChE) and human BChE (hBChE) are 266 nM and 10.6 nM , respectively [1].
T79503	PD25
	PD25, an inhibitor of both AChE and BuChE, demonstrates inhibitory constants of hAChE IC50: 1.58 μM, eeAChE IC50: 1.63 μM, and eqBuChE IC50: 2.39 μM. It exhibits antioxidant properties with a DPPH IC50 of 29.55 μM. This ...