guanosine 3':5'cyclic monophosphate sod

GUANOSINE 3':5'-CYCLIC MONOPHOSPHATE SOD (cGMP sodium salt) , also known as cGMP, is a cellular regulatory agent and has been described as a second messenger. Its levels increase in response to a variety of hormones, including acetylcholine, insulin, and oxytocin. GUANOSINE 3':5'-CYCLIC MONOPHOSPHATE SOD activates protein kinase G (PKG) and modulates ion channel conductance, with signaling affecting diverse processes including smooth muscle relaxation and proliferation, phototransduction, and energy homeostasis.

Cyclic GMP (cGMP) belongs to the class of endogenous metabolites and is a pivotal intracellular second messenger that mediates extracellular signals such as nitric oxide (NO) and natriuretic peptides (NPs). The effects of Cyclic GMP are primarily executed through three main target groups: cGMP-dependent protein kinases (PKGs), cGMP-gated cation channels, and phosphodiesterases (PDEs). Cyclic GMP is capable of inhibiting platelet adhesion and aggregation and participates in enhancing antiviral immune responses.

Cyclic GMP TBAOH is an endogenous second messenger that triggers the production of interferons in response to cytosolic DNA. It activates the stimulator of interferon genes (STING), initiating a signaling cascade that produces type I interferons and other immune mediators. The conjugate of Cyclic GMP TBAOH and AMP, known as Cyclic-GMP-AMP, can induce IRF3 phosphorylation and nuclear translocation to enhance antiviral immune responses. Additionally, Cyclic GMP TBAOH may activate PDE to degrade cAMP, inhibit the calcium current ICa in cardiomyocytes, and regulate myocardial contractility. Its derivative, 8-Br-cGMP, exhibits antiplatelet activity, making Cyclic GMP TBAOH useful for research in antiviral immunity and cardiovascular diseases.