gpr132

ONC212 [a fluorinated-ONC201 analogue] is a selective GPR132 agonist.

NOX-6-18 (GPR132-B-160) is a highly potent and selective GPR132 antagonist with insulinotropic activity that modulates macrophage reprogramming in pancreatic islets and reduces weight gain.

GPR132 antagonist 1 (GPR132-B-160, Compound 25) is a GPR132 antagonist with an EC50 value of 0.075 μM. It also exhibits insulin secretion-promoting activity, with an EC50 value of 0.7 μM.

The compound (±)11(12)-EET methyl ester (11,12-EET methyl ester) is a type of epoxyeicosatrienoic acid (EET), an endogenous lipid signaling molecule known for its cardioprotective and vasodilatory properties. (±)11(12)-EET methyl ester can bind to and activate GPR132, and it enhances hematopoietic induction and transplantation capabilities in mice and zebrafish.

Commendamide is a natural bacterial product that was discovered in a screen for commensal bacteria effector genes (Cbegs). Cbeg12 is a bacterial effector gene that encodes for its production. Commendamide is structurally similar to long-chain N-acyl-amides, which commonly signal, in mammals, through G protein-coupled receptors. Commendamide activates GPR132 (also known as G2A) with an EC50 value of 11.8 μM.

T-10418 is a highly potent and selective G2A/GPR132 agonist (EC50 = 0.82 μM) that enhances TRPV1 responses in mouse primary sensory neurons, making it suitable for studying neuropathic pain and inflammation.