glutamic acid derivative

Glutamyl-glutamic acid (Glu-glu) is an Interpeptide Bridge in the Murein of Some Micrococci and Arthrobacter sp..

Thalidomide (Thalomid) is a synthetic derivative of glutamic acid (alpha-phthalimido-glutarimide) with teratogenic, immunomodulatory, anti-inflammatory and anti-angiogenic properties.

L-Pyroglutamic acid (pidolic acid), a cyclized derivative of the L-GLUTAMIC ACID, can elevate blood levels. This function may be associated with problems of GLUTATHIONE or GLUTAMINE metabolism.

L-Allylglycine is an amino acid derivative that reduces glutamate decarboxylase (GAD) activity by 60% when administered at a dose of 39.8 μmol/g per hour ex vivo in mouse brain preparations. L-Allylglycine (1.2 mmol/kg, i.p.) induces convulsions and decreases GABA concentration throughout the cerebellum, pons, medulla, striatum, cortex, and hippocampus in mice. Chronic administration (3.2 μg/0.5 μl per hour for 13 days) of L-allylglycine in rats increases locomotor activity in an open field test and impairs attention in the 5-choice serial reaction time task (5CSRTT). In vitro, L-allylglycine inhibits GAD only when used at high concentrations (1-80 mM). The more potent in vivo activity can be attributed to metabolic conversion of L-allylglycine to 2-keto-4-pentanoic acid, a more potent convulsant and GAD inhibitor.

(R)-5-Oxopyrrolidine-2-carboxylic acid (D-Pyroglutamic acid) is a cyclic derivative of glutamic acid, physiologically present in mammalian tissues. It releases GABA from the cerebral cortex and exhibits anti-anxiety effects in a simple approach-avoidance conflict situation in rats. In clinical pharmacology experiments, it significantly shortens the plasma half-life of ethanol during acute intoxication.

H-Glu(OEt)-OEt.HCl (Diethyl L-glutamate hydrochloride) is a glutamic acid derivative.

Fmoc-L-glutamic acid 5-tert-butyl ester (Fmoc-Glu(OtBu)-OH) is a glutamic acid derivative.

Boc-Glu(OBzl)-OH (Boc-Glu(OBzl)-OH) is a glutamic acid derivative.

Dimethyl DL-glutamate is a cell-permeant glutamic acid derivative that enhances insulin release in response to glucose in isolated islets and in animal models of diabetes.

Indoleacetyl glutamic acid is a derivative of the plant hormone indole‑3‑acetic acid (IAA). As a conjugated form of IAA, indoleacetyl glutamic acid participates in IAA transport, storage, and homeostasis in plants, and can be used to explore the mechanisms by which plant hormones regulate plant growth and development.

N-Isovalerylglutamic acid is an N-acylated derivative of glutamic acid, formed by the reaction of an isovaleryl group with the amino group of glutamic acid. N-Isovalerylglutamic acid belongs to the class of organic acids associated with branched-chain amino acid metabolism.

L-Pyroglutamic acid β-naphthylamide (PYR) is a derivative of glutamic acid.

Boc-Glu(OtBu)-OH is a derivative of glutamic acid, featuring two protective groups: Boc- and OTBu.

L-γ-Glutamyl-p-nitroanilide Monohydrate is a derivative of glutamic acid.