gdp disodium

Guanosine 5'-diphosphate disodium salt (5'-GDP-Na2) is a nucleoside diphosphate, is a potential iron mobilizer, which prevents the hepcidin-ferroportin interaction and modulating the interleukin-6 (IL-6)/stat-3 pathway.

GDP-L-fucose disodium, a nucleotide sugar, serves as a crucial substrate for fucose oligosaccharides biosynthesis by providing the fucose moiety. Its formation follows two metabolic pathways: the primary de novo pathway and the secondary remedial pathway [1].

PMEG-DP disodium is an effective inhibitor of DNA polymerase (IC50=2.5 μM), exerting strong inhibitory effects particularly on DNA polymerases α and δ. As the active metabolite of GS-9191, it efficiently impedes the growth of cell lines infected with human papillomavirus (HPV). PMEG-DP disodium is useful in research related to HPV-associated diseases.

GDP-α-D-mannose disodium gives a competitive inhibition with respect to GTP (Ki 14.7 μM) and an uncompetitive inhibition with respect to mannose-1-P (Ki 115 μM).GDP-α-D-mannose disodium is the donor substrate for mannosyltransferases and the precursor of

GDP-D-mannose disodium consists of GDP-α-D-mannose and GDP-β-D-mannose. GDP-α-D-mannose serves as a donor substrate for mannosyltransferases and a precursor for GDP-β-L-fucose biosynthesis. It competitively inhibits GTP with a Ki of 14.7 μM and non-competitively inhibits mannose-1-P with a Ki of 115 μM.

Inosine-5'-diphosphoric acid disodium salt, as a decoy substrate for NM23-H2, exhibits excellent binding ability at the GDP-binding site of NM23-H2 with a dissociation constant (KD) of 5.0 μM. It can inhibit c-MYC transcription by disrupting the interaction between NM23-H2-Pu27-GQ, thereby inducing apoptosis and G2/M cell cycle arrest without affecting the kinase activity mediated by NM23-H2. Inosine-5'-diphosphoric acid disodium salt also possesses anti-hypoxic, antihypertensive, and antiarrhythmic activities, protects organisms from γ-radiation damage, and can be used in research on cancers such as Burkitt lymphoma and cardiovascular diseases.