fen 1

FEN1-IN-1 (LNT-1) is an inhibitor of flap endonuclease 1 (FEN1). FEN1-IN-1 binds to the active site of FEN1. It partly achieves inhibition by the co-ordination of Mg2+ ions.

FEN1-IN-2 is a selective and potent inhibitor of flap endonuclease 1 (FEN1), inhibits FEN1 and XPG, has potential anticancer activity, and can be used to study DNA damage repair.

FEN1-IN-4 (FEN1 Inhibitor C2) is an inhibitor of human flap endonuclease-1 (hFEN1)

FEN1-IN-SC13 is a potent inhibitor of DNA fragmentation endonuclease 1 (FEN1).

FEN1-IN-5 (compound 12A) is a potent inhibitor of Flap endonuclease-1 (FEN1) with an IC50 of 12 nM, contributing to DNA repair mechanisms [1].

FEN1-IN-6 (compound 9) is a potent Flap endonuclease-1 (FEN1, IC50 = 10 nM) inhibitor, crucial for DNA damage repair in mammalian cells, and also targets the related endonuclease xeroderma pigmentosum G (XPG) with an IC50 of 23 nM [1].

FEN1-IN-7 (compound 16), a selective Flap endonuclease-1 (FEN1) inhibitor with an IC50 of 18 nM, plays a role in DNA damage repair in mammalian cells. Additionally, it targets the related endonuclease, xeroderma pigmentosum G (XPG), with an IC50 of 3.04 μM. FEN1-IN-7 enhances the sensitivity of cancer cells to potent DNA alkylating or methylating agents [1].

FEN1-IN-3 is a human flap endonuclease-1 ( hFEN1 ) inhibitor that stabilizes hFEN1 with an EC 50 of 6.8 μM .

Ibuprofen-13C,d3 is a carbon-13 and deuterium-labeled form of Ibuprofen. It acts as an inhibitor of COX-1 and COX-2 with IC50 values of 13 μM and 370 μM, respectively, and possesses anti-inflammatory properties.

Ibuprofen-13C6 ((±)-Ibuprofen-13C6) is a 13C-labeled form of Ibuprofen. Ibuprofen ((±)-Ibuprofen) acts as an orally active COX-1 selective inhibitor with an IC50 of 13 μM. It inhibits cell proliferation and angiogenesis while inducing apoptosis. Additionally, Ibuprofen functions as a non-steroidal anti-inflammatory agent and a nitric oxide (NO) donor. It is used in research involving pain, swelling, inflammation, infections, immunology, and cancer.

trans-Hydroxy Loxoprofen-13C-d3 (Mixture of Diastereomers) the 13C and deuterated compound of trans-Hydroxy Loxoprofen. trans-Hydroxy Loxoprofen has a CAS number of 371753-19-4.