epibatidine

Epibatidine is an agonist of α7nACh with a Kd value of 100 nM. It is utilized in research related to Alzheimer's disease, Parkinson's disease, and schizophrenia.

Epibatidine 2HCl is a potent nicotinic agonist.

Hemicholinium 3 is a potent and selective choline uptake blocker.

SR 16584 is a selective α3β4 nAChR antagonist (IC50 = 10.2 μM, Ki = 0.508) that can attenuate the contractile effects induced by epibatidine.

Tebanicline is a potent synthetic nicotinic (non-opioid) analgesic drug. It was developed as a less toxic analogue of the potent poison dart frog-derived compound epibatidine. Like epibatidine, tebanicline showed potent analgesic activity against neuropat

AT-1001 (Larazotide) is an orally active tight junction regulator and Zonulin antagonist. It reduces intestinal permeability in celiac and inflammatory bowel disease models by blocking Zonulin receptor signaling to maintain the integrity of epithelial tight junctions.

Epiboxidine, a methylisoxazole analog of the alkaloid Epibatidine and analog of the nAChR agonist ABT 418 [1], serves as a potent and selective agonist for neural nicotinic acetylcholine receptors (nAChR), exhibiting Ki values of 0.46 nM and 1.2 nM for rat and human α4β2 nAChRs, respectively.

Epiboxidine hydrochloride, a methylisoxazole analog of the alkaloid Epibatidine and an analog of the nAChR agonist ABT 418 [1], serves as a potent and selective agonist of neural nAChRs, demonstrating K i values of 0.46 nM and 1.2 nM for α4β2 nAChRs in rats and humans, respectively.