double-stranded — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T12516	Polyinosinic-polycytidylic acid sodium	Poly(I:C) sodium	Apoptosis , Others , TLR
	Polyinosinic-polycytidylic acid sodium (Poly(I:C) sodium) is a synthetic analog of double-stranded RNA and an agonist of toll-like receptor 3 (TLR3) and retinoic acid inducible gene I (RIG-I)-like receptors (RIG-I and MD...		Apoptosis , Others , TLR
T4327	Prexasertib dihydrochloride	LY2606368 (dihydrochloride),Prexasertib HCl,LY2606368	Apoptosis , Chk , S6 Kinase
	Prexasertib dihydrochloride (LY2606368) is an ATP-competitive CHK1 inhibitor (Ki: 0.9 nmol/L). in the cell-free assay, its IC50 values are 8 nM and 9 nM for CHK2 and RSK, respectively.		Apoptosis , Chk , S6 Kinase
T4310	Prexasertib	LY2606368	Apoptosis , Chk
	Prexasertib (LY2606368) is an inhibitor of checkpoint kinase 1 (chk1) with potential antineoplastic activity.		Apoptosis , Chk
T20041	2'-Deoxyadenosine	NSC-141848,NSC141848,NSC 141848	Endogenous Metabolite
	2'-Deoxyadenosine (NSC-141848) is the DNA nucleoside A. It pairs with deoxythymidine (T) in double-stranded DNA.		Endogenous Metabolite
T18883	2-Di-1-ASP		Others
	2-Di-1-ASP is a mono-stryryl dye and widely used as mitochondrial stain and groove-binding fluorescent probes for double-stranded DNA. It has selective for G-quadruplex (G4) and double-stranded DNA.		Others
T23171	Polyinosinic-polycytidylic acid	Poly(I:C)	TLR
	Polyinosinic-polycytidylic acid (Poly(I:C)) is a double-stranded RNA (dsRNA) and a TLR3 agonist. Polyinosinic-polycytidylic acid induces natural immunity in mammals.		TLR
T38709	PFM39
	PFM39, a Mirin analog, is a potent and selective inhibitor of MRE11 exonuclease activity, specifically targeting the inhibition of phosphate rotation necessary for double-stranded DNA (dsDNA) exonuclease function. Import...
T19836	2-Aminopurine		DNA/RNA Synthesis , PKA
	2-Aminopurine is a double-stranded RNA-dependent protein kinase, protein kinase R (PKR) inhibitor.		DNA/RNA Synthesis , PKA
T8637	DMNB	6-Nitroveratraldehyde	DNA-PK
	DMNB (6-Nitroveratraldehyde) is DNA-dependent protein kinase (DNA-PK) inhibitor with IC50 of 15 μM, an enzyme involved in the non-homologous end-joining (NHEJ) pathway of double-stranded DNA break (DSB) repair in human c...		DNA-PK
T4434	Tirapazamine	Tirazone,Win59075,SR4233,SR259075	Others
	Tirapazamine (Win59075) is a potent cytotoxic agent under hypoxic conditions, can induce apoptosis by inducing breaks in single and double-stranded DNA, as well as chromosomal breaks. The compound sensitizes cells to oth...		Others
T6228	Irinotecan	CPT-11,Topotecin,(+)-Irinotecan	Topoisomerase , Autophagy
	Irinotecan (CPT-11), a derivative of camptothecin, is an inhibitor of DNA topoisomerase I (Topo I). Irinotecan has antitumor activity by preventing DNA strand reattachment through binding to the Topo I complex, resulting...		Topoisomerase , Autophagy
T13592	Calf thymus DNA	DNA from calf thymus, Thymonucleic acid	DNA/RNA Synthesis
	Calf thymus DNA (DNA from calf thymus, Thymonucleic acid) is a high-quality double-stranded template DNA extracted from the bovine thymus gland, which can be widely used in the study of DNA binding anticancer agents and ...		DNA/RNA Synthesis
T67931	[Tyr3]Octreotate		Others
	[Tyr3]Octreotate is a long peptide compound containing 8 amino acids and is a functional DOTA chelating agent with covalent bonds. [Tyr3]Octreotate binds to transmembrane receptors of SSR2-active NETs and is actively tra...		Others
T19003	HOE-S 785026 trihydrochloride	meta-Hoechst trihydrochloride,Meta-Hoechst trihydrochloride,HOE-S 785026 trihydrochloride (132869-83-1 free base)
	HOE-S 785026 trihydrochloride is a live cell labeling dye that binds nucleic acids by binding to the minor groove in DNA double strands. HOE-S 785026 trihydrochloride tends to bind to A/T-rich DNA strands (fluorescence i...
T4809	Pyrimidine	Metadiazine	Others , Endogenous Metabolite
	Pyrimidine (Metadiazine)s are heterocyclic, six-membered, nitrogen-containing carbon ring structures, with uracil, cytosine and thymine being the basal structures of ribose-containing nucleosides (uridine, cytidine, and ...		Others , Endogenous Metabolite
TD0003L	CelGreen nucleic acid gel stain 10,000× concentrate in DMSO
	CelGreen nucleic acid gel stain 10,000× concentrate in DMSO is a fluorescent dye with a unique involvement that binds to all dsDNA double helix sulcus regions.In the free state, the side strand and CelGreen emit weak f...
T16283	Neocarzinostatin		5-HT Receptor
	Neocarzinostatin is an effective DNA-damaging, anti-tumor antibiotic. It recognizes double-stranded DNA bulge and induces DNA double strand breaks (DSBs). Neocarzinostatin leads to apoptosis. Neocarzinostatin has potenti...		5-HT Receptor
T36298	Tyrocidine Complex
	Tyrocidine complex is a mixture of cyclic decapeptides originally isolated from B. brevis. It is active against Gram-positive and Gram-negative bacteria. It forms a complex with single- and double-stranded DNA to inhibit...
T39122	Inclisiran	ALN-PCSsc
	Inclisiran (ALN-PCSsc) is a double-stranded small interfering RNA (siRNA) compound that effectively suppresses PCSK-9 transcription. It proves promising in the investigation of hyperlipidemia and cardiovascular disease (...
T76109	Nuclease S1
	Nuclease S1, a specific endonuclease, degrades single-stranded DNA (ssDNA) and RNA, and can remove protruding single-strand ends from double-stranded DNA [1] [2].