do-1

DO1 (Disperse Orange 1) is an anti-amyloid agent which potently delays both seeded and non-seeded Aβ42 polymerization at substoichiometric concentrations

Endo-1,4-β-xylanase (Xylanase), a glycoside hydrolase enzyme that degrades arabinoxylan (AX), is commonly utilized in biochemical research. It specifically hydrolyzes the β-xylosidic bonds linking two d-xylopyranosyl residues in a β-(1,4) configuration [1].

5-Chloro-3-iodo-1H-pyrrolo[2,3-c]pyridine, with CAS No. 1190310-51-0, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. 5-Chloro-3-iodo-1H-pyrrolo[2,3-c]pyridine provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.

(3S,8R,9S,10R,13S,14S)-17-Iodo-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15-dodecahydro-1H-cyclopenta[a]phenanthren-3-ol is a useful organic compound for research related to life sciences. The catalog number is T66301 and the CAS number is 32138-69-5.

Endo-1,3-β-glucanase (Lyticase) is a glucanase from fungi and Chlamydomonas reinhardtii scallops that shows cleavage activity on fungal cells.Endo-1,3-β-glucanase randomly cleaves the β-1-3 glycosidic bond along the β-glucan chain.

Mca-(endo-1a-Dap(Dnp))-TNF-Alpha (-5 to +6) amide (human) is a peptide used as a fluorescence resonance energy transfer (FRET) based substrate for proteolytic activity assays, with cleavage-induced changes in fluorescence intensity indicating enzymatic activity [1].

rac-3-Hexadecanamido-2-methoxypropan-1-ol phosphocholine hydrate is a phospholipid that acts as an inhibitor of protein kinase C.

6-Amino-3-iodo-1-(b-D-ribofuranosyl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one is a useful organic compound for research related to life sciences and the catalog number is TNU0282.

Nucleoside Derivatives - 8-Aza-7-deaza purine nucleosides, Halo-nucleosides

Heterocyclic compound –purines, intermediate and building block; Used for modified nucleosides and nucleic acids

2-Acetamido-1,3,4,6-tetra-O-acetyl-2-deoxy-alpha-D-glucopyranose has potential applications in glycobiology research.

Methyl 3,4,6-tri-O-acetyl-2-deoxy-2-phthalimido-1-thio-β-D-glucopyranoside is a biochemical reagent used in glycobiology research. This area of study examines the structure, synthesis, biology, and evolution of sugars. It encompasses carbohydrate chemistry, glycan formation and degradation enzymology, protein-glycan recognition, and the function of glycans in biological systems. Glycobiology is closely linked to fundamental research, biomedicine, and biotechnology.

1-Azido-1-deoxy-β-D-galactopyranoside, 97% (1-Azido-1-deoxy-beta-D-galactopyranoside, 97%), is commonly used in the study of glycosylation processes and enzyme mechanisms.

6-Azido-1,6-dideoxy-3,4-O-isopropylidene-D-lyxo-2-hexulofuranose is a reagent used in biochemical reactions.

1-Azido-1-deoxy-β-D-lactopyranoside is applicable in glycoscience research.

4-Iodo-1H-imidazole is a biochemical reagent that can be used as a biomaterial for life science related research and as a sulfonylation reagent for organic synthesis and drug discovery.

Lometrexol (LY 264618), an antipurine Antifolate, can inhibit the activity of glycinamide ribonucleotide formyltransferase (GARFT) but do not induce detectable levels of DNA strand breaks. Lometrexol can further inhibit de novo purine synthesis, causing abnormal cell proliferation and Apoptosis, even cell cycle arrest. Lometrexol has anticancer activity. Lometrexol also is a potent human Serine hydroxymethyltransferase1 2 (hSHMT1 2) inhibitor.

Ensartinib (X-396) is a potent and orally active dual ALK MET inhibitor for the treatment of ALK-positive non-small cell lung cancer (NSCLC).

1. Gitogenin, tigogenin, and solasodine are novel selective inhibitors of UGT1A4, and do not inhibit the activities of major human CYP isoforms. 2. Gitogenin and (25S)-5α-furastan-3β, 22, 26-triol are the inhibitors of enzyme α-glucosidase with IC50 value

PCC0208009 (IDO-IN-2) is an IDO inhibitor.

Anti-infective agent 9 (compound 1) acts as a Plasmodium falciparum inhibitor, demonstrating an IC 50 of 600 nM. It effectively reduces pyruvate levels and disrupts the TCA cycle within Plasmodium. This compound also exhibits robust metabolic stability and minimal toxicity to human liver cells. Research indicates that the potential targets of Anti-infective agent 9 for inhibiting Plasmodium falciparum do not include 1-deoxy-D-xylulose-5-phosphate synthase (DXPS) [1].