dbco-amine

DBCO-amine is a cleavable ADC linker utilized in the synthesis of antibody-drug conjugates (ADCs)[1].

Sulfo DBCO-amine, an alkyl chain-derived PROTAC linker, is utilized for synthesizing PROTACs [1].

Azido-PEG10-amine is a non-cleavable ADC linker and PEG-based PROTAC linker that can be used to synthesise antibody-drug conjugates (ADCs) and PROTACs. It can undergo click chemistry reactions with molecules containing alkyne, DBCO or BCN groups.

Azido-PEG11-amine is a PEG-based PROTAC linker for synthesizing PROTAC molecules. Its azido group undergoes click chemistry reactions with molecules containing alkyne, DBCO, or BCN groups.

Azido-PEG7-amine is a non-cleavable ADC linker and PEG-based PROTAC linker that can be used to synthesise antibody-drug conjugates (ADCs) and PROTACs. It can undergo click chemistry reactions with molecules containing alkyne, DBCO or BCN groups.

DBCO-NHCO-PEG4-amine is a cleavable ADC linker used to conjugate MMAE and antibody (e.g., DBCO-VCpAB MMAE and DBCO-TRX MMAE with EC50s of 280 nM and 22 nM in SKBR3 cells, respectively) [1].

DBCO-PEG4-amine is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). DBCO-PEG4-amine can be used in the synthesis of FPM-PEG4-DBCO (a homobifunctional azide-to-azide cross-linker)[1].

Sulfo DBCO-PEG4-amine is a PEG-based linker for PROTACs, connecting two essential ligands crucial for forming PROTAC molecules and enabling selective protein degradation via the ubiquitin-proteasome system within cells.

DBCO-C2-PEG4-amine, a PEG-based linker for PROTACs, connects two essential ligands necessary for forming PROTAC molecules. This linker facilitates selective protein degradation by utilizing the ubiquitin-proteasome system within cells.

DBCO-C3-PEG4-amine is a PEG-based linker for PROTACs that joins two essential ligands crucial for forming PROTAC molecules, enabling selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

DBCO-NHCO-PEG12-amine is a PEG-based linker for PROTACs that joins two essential ligands, crucial for forming PROTAC molecules, and enables selective protein degradation by leveraging the ubiquitin-proteasome system (within cells).

DBCO-NHCO-PEG2-amine is a PEG-based linker for PROTACs that joins two essential ligands, enabling selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

DBCO-NHCO-PEG6-amine is a PEG-based linker used in PROTACs that joins two essential ligands for PROTAC molecule formation, enabling selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

DBCO-PEG1-amine is a PEG-based linker for PROTACs that joins two essential ligands, crucial for forming PROTAC molecules, and facilitates selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

DBCO-PEG2-amine is a PEG-based linker for PROTACs that connects two essential ligands, facilitating the formation of PROTAC molecules and enabling selective protein degradation through the ubiquitin-proteasome system within cells.

DBCO-PEG6-amine is a PEG-based linker for PROTACs that connects two essential ligands, facilitating the formation of PROTAC molecules [DBCO-PEG6-amine]. It enables selective protein degradation by utilizing the ubiquitin-proteasome system within cells.

DBCO-PEG9-amine is a PEG-based linker for PROTACs, joining two essential ligands crucial for forming PROTAC molecules, enabling selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

DBCO-SS-amine is a cleavable linker essential in ADC synthesis, facilitating the attachment of cytotoxic drugs to antibodies for targeted delivery to cells or proteins. Its cleavable nature allows for controlled drug release, enhancing the effectiveness of ADCs (antibody-drug conjugates).

Compound 3 (diABZI-V/C-DBCO) functions as an efficient STING agonist. This compound acts by releasing diABZI-amine under the action of cathepsin B to activate STING, thereby inducing the production of interferon and other immune-activating molecules, which enhances the immune system's response to tumors. In THP1-Dual cells, the EC50 values for STING activation by diABZI-V/C-DBCO and diABZI-amine are 1.47 nM and 0.144 nM, respectively, and in primary mouse splenic cells, the EC50 values are 7.7 µM and 0.17 µM, respectively. diABZI-V/C-DBCO is useful for research in the field of cancer immunotherapy.

DBCO-PEG6-amine (TFA) is a PROTAC linker classified within the PEG category, suitable for synthesizing PROTAC molecules. This compound is utilized as a click chemistry reagent and includes a DBCO group, enabling it to participate in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with azide-containing molecules.

3-Azidopropionic Acid Sulfo-NHS Ester is a water-soluble compound containing an azide group and an NHS ester. The azide group can react with alkyne, BCN, DBCO via Click Chemistry to yield a stable triazole linkage. The NHS ester can be used to label the p

DBCO-PEG3-amine, a PEG-based linker for PROTACs, joins two essential ligands and facilitates the formation of PROTAC molecules, enabling selective protein degradation through the ubiquitin-proteasome system within cells.

Sulfo DBCO-TFP Ester, a water-soluble, sulfo-containing click chemistry reagent, facilitates the efficient and straightforward incorporation of sulfo-DBCO moieties onto amine-containing molecules [1].

DBCO-PEG24-acid is a click chemistry reagent that serves as an analog of DBCO-acid featuring a PEG linker and a DBCO group. The DBCO group is typically utilized in copper-free click chemistry reactions due to its strain-promoted high energy. The hydrophilic polyethylene glycol (PEG) chain enhances water solubility. The terminal carboxylic acid group reacts with primary amine groups in the presence of activators (such as EDC or HATU), forming stable amide bonds. This compound is of reagent grade and strictly for research purposes.