columbamine

Columbamine (Columbamin) shows strong activity with IC5 48.1 μM.Columbamine exerts anti-proliferative and anti-vasculogenic effects on metastatic human osteosarcoma U2OS cells with low toxicity.

Columbamine chloride is an organic heterocyclic alkaloid and a metabolite of berberine which is widely found in Ranunculaceae plants such as Coptis and Phellodendron. Columbamine chloride induces apoptosis in cancer cells and exhibits anticancer activity. Columbamine chloride inhibits the cytochrome P450 (CYP) subtype CYP3A4 (IC50 = 30.6 µM). Columbamine chloride possesses various biological activities, including antioxidant, anti-inflammatory, antifungal, antiprotozoal, hepatoprotective, neuroprotective, lipid-lowering, and hypoglycemic effects.

Pseudocolumbamine is a natural product for research related to life sciences. The catalog number is TN6098 and the CAS number is 64191-04-4.

N-Methyltetrahydrocolumbamine is a natural product that can be used as a reference standard. The CAS number of N-Methyltetrahydrocolumbamine is 92758-34-4.

(+)-Isocorypalmine is a natural product discovered in Corydalis ophiocarpa, capable of displacing SCH23390 at D1 receptors and spiperone at D2 receptors in HEK293 cells.

(-)-Isocorypalmine ((S)-Tetrahydrocolumbamine), a natural product isolated from Corydalis chaerophylla, has significant antifungal activity.