chikv-in-2

CHIKV-IN-2, a chemical compound, exhibits potent inhibitory activity against the enzyme Dihydroorotate Dehydrogenase (DHODH), crucial for pyrimidine synthesis affecting various viruses' replication. It serves as an effective Chikungunya virus (CHIKV) inhibitor, demonstrating significant cellular antiviral activity (EC90=270 nM) and enhanced liver microsomal stability[1].

CHIKV nsP2 protease-IN-1 (compound J13) is an orally active inhibitor of non-structural protein 2 protease (non-structural protein 2protease), exhibiting an EC50 value of 0.39 μM against CH S27. This compound is utilized in the research of Chikungunya virus.

CHIKV nsP2 protease-IN-3 (Compound 5) is an irreversible covalent inhibitor targeting the cysteine protease of chikungunya virus (CHIKV) non-structural protein 2 (nsP2), with an IC50 of 0.5 μM. It effectively inhibits the replication of viral RNA and shows potential for research on alphaviruses.

CHIKV nsP2 protease-IN-2 (Compound 2o) is an allosteric inhibitor of the non-structural protein 2 helicase (nsP2hel), with IC50 values of 0.5 μM for nsP2 ATPase and 0.9 μM for RNA helicase. It exhibits broad-spectrum antiviral activity against alphaviruses, effectively targeting Chikungunya virus (CHIKV), Mayaro virus (MAYV), and Venezuelan equine encephalitis virus (VEEV), with an EC50 of 0.12 μM against CHIKV-nLuc. This compound is useful for research on alphavirus infections.