cefotaxim

Cefotaxime is a third-generation cephalosporin antibiotic. Like other third-generation cephalosporins, it has broad spectrum activity against Gram positive and Gram negative bacteria. In most cases, it is considered to be equivalent to ceftriaxone in terms of safety and efficacy. Cefotaxime sodium (Cefotaxim sodium salt) is marketed under various trade names including Claforan (Sanofi-Aventis).

Cefotaxime is an inhibitor of penicillin binding protein.

Desacetylcefotaxime, an in vivo metabolite of Cefotaxime (CTX), exhibits noteworthy in vitro antimicrobial efficacy, akin to its parent compound, against a broad spectrum of aerobic and anaerobic bacteria [1].

Cefotaxime-d3 is the deuterium-labeled form of Cefotaxime. Cefotaxime is a cephalosporin stable against β-lactamase, classified as a third-generation cephalosporin antibiotic. It exhibits broad-spectrum antibacterial activity against a variety of Gram-positive and Gram-negative bacteria.

3-Desacetyl Cefotaxime lactone, the active metabolite of Cefotaxime, is derived from its sodium salt form, which is recognized as a third-generation cephalosporin antibiotic.

Desacetylcefotaxime is an active metabolite of the cephalosporin antibiotic cefotaxime .1It is active against 60 clinical isolates derived from patients with meningitis, includingH. influenzae,S. pneumoniae,S. agalactiae, andN. meningitidis(MIC90s = 0.008-0.12 μg/ml). 1.Jones, R.N.Cefotaxime and desacetylcefotaxime antimicrobial interactions. The clinical relevance of enhanced activity: A reviewDiagn. Microbiol. Infect. Dis.22(1-2)19-33(1995)