ce-6

Chlorin E6 (CE6) is a second-generation photosensitizer with antitumor activity when used in combination with irradiation. In a mouse model of implanted fibrosarcoma, Chlorin E6 (2.5-10 mg/kg, i.v., 50-200 J/cm2 irradiation) resulted in complete tumor disappearance after varying degrees of irradiation. Agents including Chlorin E6 were tested in a Phase I clinical study in patients with early superficial squamous cell carcinoma of bronchial origin with favorable results (40 mg/m2, IV, 100 J/cm2 laser irradiation). In a Phase II clinical trial in patients with early stage lung cancer, the same mode of administration resulted in a complete response in 82.9% of patients. Chlorin E6 has been investigated as a nanotechnology drug delivery tool.

Chlorin e6 trisodium (Ce6 trisodium) is a water-soluble derivative of chlorophyll and belongs to the chlorin photosensitizers with an absorption wavelength range of 600–670 nm. Upon photoexcitation, Chlorin e6 trisodium can produce characteristic red fluorescence for real-time observation of tumor boundaries and disease progression. Chlorin e6 trisodium can be used in photodynamic therapy (PDT)-related research and fluorescence diagnosis research of malignant tumors such as bladder cancer and related neoplastic lesions.

6-Palmitamidohexyl CE phosphoramidite is a monomer raw material used for nucleic acid synthesis.

6'-O-DMTr-2'-O-Me-5'-Homo-C(Ac)-3'-CE-phosphoramidite is a monomeric material used in nucleic acid synthesis.

DMTr-2'-O-Me-6-Deamino-6-(m-benzenepropanoic acid 2-cyanoethyl ester)-rA-3'-CE-phosphoramidite is a monomeric material used in nucleic acid synthesis.

6'-O-DMTr-2'-O-Me-5'-homo-A(Bz)-3'-CE-phosphoramidite is a monomeric material used in nucleic acid synthesis.

6'-O-DMTr-2'-O-Me-5'-Homo-U-3'-CE-phosphoramidite is a monomeric material utilized in the synthesis of nucleic acids.

6'-O-DMTr-2'-O-Me-5'-Homo-G(iBu)-3'-CE-phosphoramidite is a monomeric material utilized in nucleic acid synthesis.