cationic lipid

DOTMA (N-(1-(2,3-dioleyloxy)propyl)-N,N,N-trimethylammonium) is a tetra-methylated DOTA analogue. DOTMA is a cationic lipid and can be used as a non-viral vector for gene therapy. It has been used as a component in liposomes that can be used to encapsulate siRNA, microRNAs, and oligonucleotides and for gene transfection in vitro. It exhibits effective in vitro and in vivo gene transfection. DOTMA induces a positive charge on the liposomes and thus promotes efficient liposome- cell membrane interaction.

DOTAP chloride (1, 2-dioleoyl-3-trimethylammonium-propane chloride) is an efficient cationic lipid, and its target is mainly the negatively charged components on the cell membrane. DOTAP chloride binds to negatively charged nucleic acids (such as DNA and RNA) by electrostatic interaction to form complexes, thereby achieving the delivery of nucleic acids.

D-Lin-MC3-DMA, an ionizable cationic lipid, serves as a potent siRNA delivery vehicle.

5A2-SC8 is an ionizable cationic lipid that is an ideal vehicle for the delivery of small RNAs, interacts with negatively charged cell membranes, and can be used for gene delivery and drug delivery.

SM-102 is the only ionizable amino cationic lipid currently clinically approved for RNA therapeutics and can be used to synthesize lipid nanoparticles (LNPs). It shows potential in the development of LNPs for the delivery of mRNA-based vaccines.

DODAP is an ionic cationic lipid with low cytotoxicity and high transfection efficiency that can be used to synthesize liposomes and encapsulate biologically active molecules such as mRNA, siRNA and plasmid DNA.

7-Oxotridecanedioic acid, a biodegradable cationic lipid intermediate, facilitates the formation of lipid nanoparticles. This compound enables the incorporation into lipid particles for the efficient delivery of active agents [1].

DOPE (DOPE) is a neutral helper lipid for cationic liposomes.It is used in combination with cationic phospholipids to increase efficiency during DNA transfection studies as a non-viral method of gene delivery.

Dimethyldioctadecylammonium (DDA) is a cationic amphipathic lipid. DDA liposomes containing an Ag85B-ESAT-6 antigen induce antigen deposition at an intramuscular or subcutaneous injection site in mice, increasing immune cell exposure to the antigen. In a guinea pig model of M. tuberculosis infection, spleen bacterial load is reduced and lung and spleen lesion numbers are decreased when the mycobacterial lipid antigens Ac2SGL and PIM2 are administered in liposomes comprised of DDA and a synthetic analog of the mycobacterial cord factor trehalose 6,6-dibehenate (TDB). DDA has also been used in the study of lipid bilayer dynamics.

93-O17S is a chalcogen-containing cationic lipidoid. It has been used in the synthesis of lipid nanoparticles (LPNs) for the delivery of Cre recombinase and ribonucleoproteins for genome editing in mice. LPNs containing 93-O17S have been utilized for the intratumoral delivery of cGAMP to enhance cross-presentation of tumor antigens and stimulation of interferon genes [STING] activation in a B16 F10 murine melanoma model.

CLinDMA, a cationic lipid, is known to induce an inflammatory response and serves as a precursor in the synthesis of LNP201, a liposome assembly designed for the systemic delivery of siRNA [1].

BGTC, a non-amino acid cationic lipid, serves as a vehicle for nucleic acid delivery [1].

DOSPA, a cationic lipid, exhibits significant potential when formulated with DNA as a transfection system [1].

DOIC (a cationic lipid) is utilized in RNA vaccines [1].

Transfectam, a cationic lipid, forms complexes with DNA, facilitating efficient gene transfer into a range of eukaryotic cells [1].

EDMPC, a cationic lipid, exhibits an enhanced capability for DNA delivery to pulmonary tissues. It facilitates intralobar DNA transfer in rodents [1].

Fluorescent DOTAP, a cationic lipid, aids research in the delivery of nucleic acids and proteins [1].

MVL5, a non-degradable multivalent cationic lipid, serves as a highly efficient vector for both DNA and siRNA [1].

16:0 EPC chloride, a saturated cationic lipid and a P-O-ethyl derivative, functions as a DNA and RNA transfecting agent. It is also utilized as a co-adjuvant in vaccine preparation and to enhance drug delivery [1].

1,2-Dimyristoyl-3-dimethylammonium-propane (14:0 DAP) is a cationic lipid utilized in drug delivery [1].

14:0 EPC chloride, an acyl cationic lipid, is utilized in the formation of liposomes for drug delivery applications [1].

16:0-18:1 EPC chloride, a cationic lipid, is utilized in the formation of liposomes for drug delivery applications [1].

DOBAQ, a pH-sensitive cationic lipid, is utilized in the formulation of liposomes for drug delivery applications [1].

DLin-K-C3-DMA is a cationic lipid that binds to negatively charged mRNA and siRNA, commonly used in the synthesis of lipid nanoparticles (LNP) for nucleic acid delivery.