caspase 3 inhibitor i

Caspase-3 Inhibitor I (N-acetyl-asp-glu-val-asp-al) is a specific inhibitor of Caspase-3.

Caspase-3/7 inhibitor I is a potent and reversible inhibitor of caspase-3 and caspase-7, with Ki values of 60 and 170 nM, respectively. It effectively inhibits apoptosis in Jurkat cells and chondrocytes treated with Camptothecin.

TopoisomeraseI/II-IN-1 is a dual inhibitor of Topoisomerase I and II. It induces G2/M cell cycle arrest and apoptosis (apoptosis) in cancer cells by increasing the levels of p53, p21, Bax mRNA, and caspase-3 proteins, as well as the Bax/Bcl-2 ratio, while decreasing Bcl-2 levels. This compound is useful for research on various cancers such as melanoma, renal cancer, colorectal cancer, and breast cancer.

MC-AcLys-GDEVD-PABC-Exatecan is a component of an antibody-drug conjugate (drug-linker conjugate for ADC) composed of an ADC linker (MC-AcLys-GDEVD-PABC) attached to the DNA topoisomerase I inhibitor, Exatecan. It operates by enhancing the release of small molecule drugs into the tumor microenvironment through a significant bystander effect, triggered by caspase-3-induced extracellular cleavage of the linker.

MMPSI (Caspase-3/7 Inhibitor I) is a novel, non-peptide small molecule caspase 3 and caspase 7 inhibitor that reduces ischemic injury in isolated rabbit heart or cardiomyocytes and inhibits apoptosis of H16c2 cells in a concentration-dependent manner.MMPSI can be used to study cardioprotection and myocardial injury.

1. Soyasaponin Bb (Soyasaponin I) can suppress Eca-976 cell growth, reverse effects on over expression of c-met, VEGF, and induce cell apoptosis through inhibiting HDAC1-NF-kappaB and activating PETEN and caspase-3 signaling pathways.

BDS-I, a marine toxin derived from Anemonia sulcata, functions as a selective inhibitor of the potassium channel, specifically targeting Kv3.4. It impedes the Aβ1-42-induced augmentation of Kv3.4 activity, caspase-3 activation, and distortion of nuclear morphology in NGF-differentiated PC-12 cells. Moreover, BDS-I effectively counteracts the cell death induced by the Aβ peptide [1].