capacitation

Cholesteryl sulfate sodium (Sodium Cholesteryl Sulfate) is a sterol sulfate in human plasma. Cholesteryl sulfate sodium is a component of cell membrane and has a regulatory function. Cholesteryl sulfate sodium also activates multiple protein kinase C (PKC) iso-enzymes, especially the ε, η and ζ isoforms.

Cholesterol sulfate is a multifunctional endogenous sterol sulfate and selective DOCK2 inhibitor with an IC50 of 2 μM in mouse assays. Cholesterol sulfate plays multiple roles including in epidermal barrier formation by regulating keratinocyte differentiation and corneocyte desquamation, functions as a serine-protease inhibitor, acts as a glucocorticoid receptor antagonist, and activates RORα/γ in the thymus. Cholesterol sulfate serves as a critical research tool for investigating cutaneous biology, immunomodulation, steroid metabolism, sperm capacitation, platelet aggregation, and disorders such as X-linked ichthyosis.

Corza6 is a potent and selective peptide inhibitor of the human voltage-gated proton channel (hHv1). It binds to the external voltage sensor domain (VSD) loop in hHv1 at a resting membrane potential (RMP) of natural hyperpolarization in mammalian cells with a Kd of approximately 1 nM. Corza6 facilitates sperm capacitation and permits sustained production of reactive oxygen species (ROS) in leukocytes (WBC).

Corza6 TFA is a potent and selective peptide inhibitor of the human voltage-gated proton channel (hHv1). It binds to the external voltage-sensor domain (VSD) loop of hHv1 with a dissociation constant (Kd) of approximately 1 nM under the native hyperpolarized resting membrane potential (RMP) of mammalian cells. Additionally, Corza6 TFA induces sperm capacitation and enables continuous reactive oxygen species (ROS) production in white blood cells (WBC).