bt549

PK11000 is a p53 targeting compound, has anti-tumor activities through activation of unstable p53.

Tubulin inhibitor 8 is an inhibitor of tubulin and various cancer cell lines and inhibits tubulin polymerisation and K562 cell growth with an IC50 of 0.73 μM and 14 nM respectively.

Camptothecin (CPT) belongs to the alkaloid group of natural products and is a specific DNA topoisomerase I (Topo I) inhibitor (IC50=679 nM) with specificity. Camptothecin has antitumor activity and induces apoptosis.

(-)-Agelastatin A is a member of the pyrrole-aminoimidazole marine alkaloid (PAI) family, capable of inhibiting β-catenin, GSK-3β, and osteopontin (OPN), exhibiting antiproliferative activity against various cancers such as leukaemia and breast cancer, and possessing a certain ability to penetrate the central nervous system (CNS).

Tubulin inhibitor 6 (iHAP1) is an inhibitor of tubulin and a potent inhibitor of multiple cancer cell lines.

WRG-28 is a potent and selective, allosteric discoidin domain receptor 2 (ddr2) inhibitor(IC50 : 230 nM)

BG11 promotes the accumulation of Fe2+ and intracellular lipid peroxides, leading to ferroptosis (iron-dependent cell death). It regulates the expression of Bax and Bcl-2 proteins, inducing apoptosis (programmed cell death) in MDA-MB-231 cells. BG11 also causes cell cycle arrest at the G0 G1 and S phases, inhibiting the proliferation of TNBC cancer cells, with IC50 values of 0.49 μM for MDA-MB-231 and 0.52 μM for BT549. Additionally, it reduces cell migration and invasion and demonstrates antitumor effects in mouse models.

Diacetylcercosporin, a perylenequinone produced by Cercospora and Septoria, exhibits diverse biological activities including inhibition of P. falciparum strains sensitive and resistant to chloroquine and L. donovani parasites (IC50 = 3.1 μM) in vitro. It shows cytotoxicity against SK-MEL, KB, BT549, and SK-OV-3 human cancer cell lines (IC50s = 4.8-8.7 μM) and acts as a phytotoxin, inhibiting the growth of lettuce and bentgrass at a concentration of 1.62 mM.

4-oxo Docosahexaenoic acid (4-oxo DHA) is a putative metabolite of DHA with antiproliferative and PPARγ agonist activity. It inhibits the growth of several triple-negative breast cancer cell lines [MCF-10F, trMCF, bsMCF, MDA-MB-231, and BT549] at 50-100 μM but increases the proliferation of MCF-7 cells. 4-oxo DHA binds covalently to PPARγ and activates gene transcription in luciferase reporter assays and dendritic cells with EC50 values of approximately 8-16 μM.