bptf

NVS-BPTF-1 is a specific inhibitor of bromodomain and PHD finger containing transcription factor (BPTF), exhibiting a dissociation constant (K_D) of 71 nM [1].

BPTF-IN-1 (compound AU1) is a selective BPTF bromodomain inhibitor (Kd: 2.8 μM) that is more selective for BPTF than for the BRD4 bromodomain.BPTF-IN-1 has an antimalarial effect.

BPTF-IN-BZ1 is a BPTF inhibitor that possesses a high potency with a Kd of 6.3 nM.

GSK1379725A is a selective BPTF ligand [Kd = 2.8 μM].

NDH-1 inhibitor-1 is an effective NDH-1 inhibitor, which can inhibit bovine SMP (mitochondrial granules), potato SMP and Escherichia coli, with pI50 values of <4, 5.40, 6.15 µM, respectively.

GSK1379767A is a dual inhibitor of BPTF and Brd4.

DC-BPi-03 is a potent BPTF-BRD inhibitor, exhibiting an IC50 of 698.3 nM and a Kd of 2.81 μM.

DC-BPi-11, a potent inhibitor of the bromodomain PHD finger transcription factor (BPTF), exhibits significant anti-proliferative effects against leukemia cells with an IC50 value of 698 nM.

DC-BPi-11 hydrochloride is a BPTF (bromodomain PHD finger transcription factor) inhibitor with an IC50 value of 698 nM, demonstrating significant anti-proliferative effects on leukemia cells [1].

TP-238 hydrochloride is a highly potent and selective dual CECR2 BPTF probe, demonstrating IC50 values of 30 nM and 350 nM, respectively. It additionally exerts inhibitory effects on BRD9, with a pIC50 value of 5.9, while displaying lower activity against 338 other kinases.

TP-238, a potent and selective dual CECR2 BPTF probe, exhibits IC50 values of 30 nM and 350 nM, respectively. Additionally, it inhibits BRD9 with a pIC50 of 5.9, demonstrating lesser activity against another 338 kinases [1] [2].