azide c2 azide

Azide-C2-Azide, a cleavable linker crucial in ADC (Antibody-Drug Conjugate) synthesis, joins cytotoxic drugs to antibodies, enabling precise delivery to target cells or proteins. Its cleavable nature ensures controlled drug release, optimizing the effectiveness of ADCs.

Ald-C2-PEG4-azide is a PEG-based linker for PROTACs that joins two essential ligands, enabling selective protein degradation through the ubiquitin-proteasome system within cells.

Azide-C2-SS-C2-biotin is a cleavable linker used in the synthesis of antibody-drug conjugates (ADCs)[1].

Boc-N-Amido-PEG2-C2-azide is a polyethylene glycol (PEG)-based linker used in the synthesis of proteolysis-targeting chimeras (PROTACs) [1].

Bromo-PEG2-C2-azide is a non-cleavable ADC linker employed in the synthesis of antibody-drug conjugates (ADCs)[1].

N-Boc-N-bis(C2-PEG1-azide) is an alkyl/ether-based PROTAC linker suitable for synthesizing PROTACs [1].

NH-bis(C2-PEG1-azide) is a PEG-based linker for PROTACs that joins two essential ligands, enabling selective protein degradation through the ubiquitin-proteasome system within cells.

Ald-Ph-amido-C2-PEG3-azide, a PEG-based linker for PROTACs, joins two essential ligands necessary for forming PROTAC molecules and facilitates selective protein degradation via the ubiquitin-proteasome system within cells.

AZD-CO-C2-Ph-amido-Ph-azide is an alkyl chain-derived PROTAC linker suitable for the synthesis of PROTACs [1].

Bromo-PEG1-C2-azide, a PEG-based PROTAC linker, is utilized in the synthesis of PROTACs.

Amino-PEG12-C2-azide is a PROTAC linker of the PEG class, utilized in the synthesis of PROTAC molecules. It acts as a click chemistry reagent and features an azide group that can engage in copper-catalyzed azide-alkyne cycloaddition reactions (CuAAC) with molecules containing alkyne groups. Additionally, it participates in strain-promoted azide-alkyne cycloaddition (SPAAC) reactions with molecules that possess either DBCO or BCN groups.

Azido-PEG23-C2-azide is a PROTAC linker within the PEG class, utilized for the synthesis of PROTAC molecules. This compound acts as a click chemistry reagent, featuring azide groups that can undergo copper-catalyzed azide-alkyne cycloaddition reactions (CuAAc) with molecules containing alkyne groups. Additionally, it facilitates strain-promoted azide-alkyne cycloaddition (SPAAC) with molecules possessing DBCO or BCN groups.

(S,R,S)-AHPC-amide-PEG5-C2-azide (VH032-CO-(CH2)2-(O-CH2-CH2)5-azide) is a PROTAC linker. This compound is utilized in the synthesis of PROTAC molecules.

Pomalidomide-C2-amide-C5-azidea, a derivative of pomalidomide, can be used to synthesize an efficient PROTAC molecule targeting CDK9 and enhances antiproliferative activity [1].

HS-PEG3-CH2CH2N3 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

N-DBCO-N-bis(PEG2-C2-NHS ester) is a PEG-like PROTAC linker that can be used to synthesize PROTAC molecules, and also contains a DBCO moiety for click chemistry with azide groups.

Boc-PEG1-PPG2-C2-azido is a PROTAC linker of the PEG class, utilized in PROTAC molecule synthesis. This compound acts as a click chemistry reagent containing an azide group, enabling copper-catalyzed azide-alkyne cycloaddition reactions (CuAAc) with alkyne-containing molecules. Additionally, it participates in strain-promoted azide-alkyne cycloaddition reactions (SPAAC) with molecules containing DBCO or BCN groups.