anti-metastatic

Ganoderic acid F exhibits antitumor and antimetastatic activities through inhibition of angiogenesis and alteration of proteins involving cell proliferation and/or cell death, carcinogenesis, oxidative stress, calcium signaling, and endoplasmic reticulum

1. Dehydrocorydaline (13-Methylpalmatine) exerts anti-metastatic potential via suppression of MMPs and Bcl-2 signaling in NSC-LC cells. 2. Dehydrocorydaline stimulates p38 MAPK activation, which can enhance heterodimerization of MyoD and E proteins, thus resulting in MyoD activation and myoblast differentiation. 3. Dehydrocorydaline shows antiplatelet effects, it inhibits thrombin-induced platelet aggregation in a low dose ( IC50= 34.914 ug/mL). 4. Dehydrocorydaline has anti-inflammatory and antinociceptive effects. 5. Dehydrocorydaline inhibits MCF-7 cell proliferation by inducing apoptosis mediated by regulating Bax/Bcl-2, activating caspases as well as cleaving PARP.

Benzyl isothiocyanate (Benzoylthiocarbimide) (BITC) is an isothiocyanate originally found in cruciferous vegetables. It shows immunomodulatory, anti-parasitic, antibiotic, antioxidative, anti-atherosclerotic, anti-angiogenic, anti-metastatic, anticancer chemotherapeutic, and chemopreventive activities.

S-Adenosyl-L-methionine disulfate tosylate is a methyl donor with oral activity. S-Adenosyl-L-methionine disulfate tosylate is a dietary supplement with effective antidepressant and pain-relieving effects. S-Adenosyl-L-methionine disulfate tosylate also has anti-proliferative, pro-apoptotic and anti-metastatic effects in cancer. S-Adenosyl-L-methionine can be used in the research of liver diseases and osteoarthritis.

β-Ionone (β-lonone) is an end-ring analog of β-carotenoids which widely distributed in fruit and vegetables,with anti-proliferative, anti-metastatic

p-Terphenyl is a triphenyl derivative used in industry as a heat transfer medium and dye carrier, and can be used for related research in the life sciences.

NMac1 (Nm23 activator 1) is a natural compound, cassumunene, derived from Zingiber cassumunar Roxb. and traditionally used as an anti-inflammatory agent in East Asia. NMac1 exhibits anti-metastatic potential by directly interacting with the C-terminal of Nm23-H1, activating its NDP kinase (NDPK) enzymatic activity in vitro. NMac1 inhibits breast cancer metastasis in vivo.

Columbamine (Columbamin) shows strong activity with IC5 48.1 μM.Columbamine exerts anti-proliferative and anti-vasculogenic effects on metastatic human osteosarcoma U2OS cells with low toxicity.

α-Carotene is a natural carotenoid and precursor to vitamin A, exhibiting antioxidant and potential anti-cancer properties; high dietary intake of α-carotene may reduce prostate cancer risk.

Meleagrin, a roquefortine C-derived alkaloid produced by Penicillium fungi, serves as both a class of FabI inhibitors and a lead c-Met inhibitory entity for controlling c-Met-dependent metastatic and invasive breast malignancies. It exhibits antimicrobial and anti-proliferative activities.

Maclurin (NSC-83240) is a phenolic component of mulberry twigs, exerts anti-metastatic effects. Maclurin effectively protects against OH-induced damages to DNA and MSCs and can be used in studies about the prevention of many diseases or MSCs transplantation.

1. Coptisine (Coptisin) treatment increases cell viability based on its reversal effect on the enhanced activity of Indoleamine 2, 3-dioxygenase . 2. Coptisine treats myocardial I/R likely through suppressing myocardial apoptosis and inflammation by inhibiting the Rho/ROCK pathway. 3. Coptisine is a potential anti-osteosarcoma drug candidate, via exerting a strong anti-osteosarcoma effect with very low toxicity . 4. Coptisine with a high dosage could inhibit cholesterol synthesis via suppressing the HMGCR expression and promoting the use and excretion of cholesterol via up-regulating LDLR and CYP7A1 expression. 5. Coptisine suppresses adhesion, migration and invasion of MDA-MB-231 breast cancer cells in vitro, the down-regulation of MMP-9 in combination with the increase of TIMP-1 possibly contributing to the anti-metastatic function for breast cancer.

Martynoside is an active glycoside extracted from Rehmannia, with anti-estrogen, anticancer, cytotoxic, hematopoietic, antioxidant, and anti-metastatic properties. It increases IGFBP3 levels through the ER pathway.

S-Adenosyl-L-methionine disulfate tosylate (Standard) is a reference standard for research and analysis in studies involving S-Adenosyl-L-methionine disulfate tosylate. S-Adenosyl-L-methionine disulfate tosylate is a methyl donor with oral activity. S-Adenosyl-L-methionine disulfate tosylate is a dietary supplement with effective antidepressant and pain-relieving effects. S-Adenosyl-L-methionine disulfate tosylate also has anti-proliferative, pro-apoptotic and anti-metastatic effects in cancer. S-Adenosyl-L-methionine can be used in the research of liver diseases and osteoarthritis.

Licoricidin, is a potent anti-metastatic agent, which can markedly inhibit the metastatic and invasive capacity of malignant prostate cancer cells.

Bisacurone has anti-oxidant, anti-inflammatory, and anti-metastatic activities, it may have a protective effect against ethanol-induced liver injury by suppressing hepatic oxidation and inflammation.

ExcisaninA may be a potent inhibitor of AKT signaling pathway in tumor cells, it can inhibit invasion by suppressing MMP-2 and MMP-9 expression, it may be a potential anti-metastatic chemotherapeutic agent for the treatment of breast cancer. Excisanin A shows comparable inhibitory effects on the LPS-induced production of NO and PGE2, and activation of NF-kappaB without affecting cell viability.Excisanin A induces apoptosis in colon cancer cell line SW620 as determined by Annexin V staining, the cleavage of caspase-3 and the proteolytic degradation of poly (ADP-ribose) polymerase (PARP).

Ganoderenic acid H is one compound of triterpenoids isolated from Ganoderma lucidum, triterpenoids exhibit a broad spectrum of anti-cancer properties, including anti-proliferative, anti-metastatic and anti-angiogenic activities.

Barakol, a primary compound found in Cassia siamea, inhibits MMP-3 activity and enhances the anti-metastatic effects of doxorubicin. Additionally, Barakol induces apoptosis (Apoptosis), generates reactive oxygen species, increases the Bax/Bcl-2 expression ratio, and activates caspase-9. This compound also exhibits laxative, anti-anxiety, central nervous system depressant, antioxidant, and anticancer properties.