Shopping Cart
  • Remove All
  • TargetMol
    Your shopping cart is currently empty
Filter
Applied FilterClear all
TargetMol | Tags By Target
  • GPCR
    (2)
  • Others
    (3)
Filter
Search Result
Results for "

amg 837

" in TargetMol Product Catalog
  • Inhibitors & Agonists
    5
    TargetMol | Inhibitors_Agonists
AMG 837
AMG837
T14216865231-46-5
AMG 837 is a novel and potent GPR40 FFA1 agonist that enhances insulin secretion and lowers blood glucose levels in rodents.
  • TBD
35 days
Size
QTY
AMG 837 sodium salt
T14215865231-45-4
AMG 837 sodium salt is a potent GPR40 agonist(EC50=13 nM) with a superior pharmacokinetic profile and robust glucose-dependent stimulation of insulin secretion in rodents. IC50 value: 13 nM (EC50) [1] Target: GPR40 agonist AMG 837 displayed the expected t
  • $1,820
1-2 weeks
Size
QTY
AMG 837 hemicalcium
T628481291087-14-3
AMG 837 hemicalcium is a potent, orally active GPR40 FFA1 partial agonist that inhibits the specific binding of [3H]AMG 837 to the human FFA1 receptor (pIC50: 8.13). It promotes insulin secretion and reduces glucose levels in rodents.
  • TBD
35 days
Size
QTY
AMG 837 calcium hydrate
TQ00201259389-38-2
AMG 837 calcium hydrate, a potent GPR40 agonist with an EC50 of 13 nM, exhibits high selectivity over GPR41, GPR43, and GPR120 (EC50 > 10,000 nM).
  • $31
In Stock
Size
QTY
AM-3189
T68356916219-50-6
AM-3189 is a potent and selective GPR40 Agonist with minimal CNS penetration, superior pharmacokinetic properties and in vivo efficacy comparable to AMG 837. AM-3189 maintains the in vivo efficacy of AMG 837 while displaying a superior pharmacokinetic profile and minimal CNS exposure. Similar to AMG 837, while highly potent on GPR40, AM-3189 was highly selective over the closely related GPCRs, GPR41 and GPR43. 13kdemonstrated low clearance, moderate volume of distribution, and good oral bioavailability. AM-3189 does not penetrate the rat CNS as indicated by a rat brain to plasma ratio of 0.04 at 3 h after an oral dose of 5 mg kg.
  • $2,420
10-14 weeks
Size
QTY